Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 2784482..2785207 Replicon chromosome
Accession NZ_CP076386
Organism Dickeya dadantii strain S3-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KNV89_RS12315 Protein ID WP_216281276.1
Coordinates 2784887..2785207 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KNV89_RS12310 Protein ID WP_216281267.1
Coordinates 2784482..2784817 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNV89_RS12280 (KNV89_12280) 2779629..2779832 - 204 WP_216281255.1 AlpA family phage regulatory protein -
KNV89_RS12285 (KNV89_12285) 2780233..2781327 + 1095 WP_216281257.1 hypothetical protein -
KNV89_RS12290 (KNV89_12290) 2781773..2782237 + 465 WP_216281259.1 hypothetical protein -
KNV89_RS12295 (KNV89_12295) 2782475..2782999 + 525 WP_216281261.1 hypothetical protein -
KNV89_RS12300 (KNV89_12300) 2783397..2783891 + 495 WP_216281263.1 hypothetical protein -
KNV89_RS12305 (KNV89_12305) 2783969..2784442 + 474 WP_216281265.1 DNA repair protein RadC -
KNV89_RS12310 (KNV89_12310) 2784482..2784817 + 336 WP_216281267.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KNV89_RS12315 (KNV89_12315) 2784887..2785207 + 321 WP_216281276.1 TA system toxin CbtA family protein Toxin
KNV89_RS12320 (KNV89_12320) 2785325..2786158 + 834 WP_216281278.1 DUF4942 domain-containing protein -
KNV89_RS12325 (KNV89_12325) 2786271..2786519 + 249 WP_039345626.1 ribbon-helix-helix domain-containing protein -
KNV89_RS12330 (KNV89_12330) 2786523..2786798 + 276 WP_216281280.1 type II toxin-antitoxin system RelE/ParE family toxin -
KNV89_RS12335 (KNV89_12335) 2786846..2787358 + 513 WP_216281282.1 AAA family ATPase -
KNV89_RS12340 (KNV89_12340) 2787876..2789132 + 1257 WP_216281284.1 tyrosine-type recombinase/integrase -
KNV89_RS12345 (KNV89_12345) 2789178..2790122 + 945 WP_216281286.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11951.66 Da        Isoelectric Point: 5.0492

>T205600 WP_216281276.1 NZ_CP076386:2784887-2785207 [Dickeya dadantii]
MQTSPAIPPREDNPCASPVAVWQQLLTYLLEKHYGLTLNDTPFCEENVIQAHIDAGVTLVNAVNFLVEKYELVRIDRNGF
NWQEQSPFLTAVDVLRARRATGLLKA

Download         Length: 321 bp

>T205600 NZ_CP101766:126184-126333 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12480.24 Da        Isoelectric Point: 6.8788

>AT205600 WP_216281267.1 NZ_CP076386:2784482-2784817 [Dickeya dadantii]
MPSSDTPEWGLKCAITRRFGARLVQEGNRLHYLADRASIVGTFSKTEAQSLERCFPELIKLLEQKLRMGELNPRQQSCVT
LYCNEWTCEADTLGSVGYVYIAIYPSSAATQ

Download         Length: 336 bp

>AT205600 NZ_CP101766:c126139-126080 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References