20560

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3755939..3756606 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag BQ2027_RS17440 Protein ID WP_003417916.1
Coordinates 3755939..3756331 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag BQ2027_RS17445 Protein ID WP_003912214.1
Coordinates 3756331..3756606 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS17425 (BQ2027_MB3413C) 3751309..3753147 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
BQ2027_RS17430 (BQ2027_MB3414C) 3753144..3754133 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
BQ2027_RS17435 (BQ2027_MB3415C) 3754133..3755185 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
BQ2027_RS17440 (BQ2027_MB3416C) 3755939..3756331 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ2027_RS17445 (BQ2027_MB3417C) 3756331..3756606 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BQ2027_RS17450 (BQ2027_IS1560-2) 3756788..3758159 + 1372 Protein_3487 ISNCY family transposase -
BQ2027_RS17455 (BQ2027_MB3420) 3758349..3760598 + 2250 WP_010950881.1 PE family protein -
BQ2027_RS17460 (BQ2027_MB3421C) 3760669..3761541 - 873 WP_010950882.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3757482..3758159 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T20560 WP_003417916.1 NC_002945:c3756331-3755939 [Mycobacterium tuberculosis variant bovis AF2122/97]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T20560 NC_002945:c3756331-3755939 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT20560 WP_003912214.1 NC_002945:c3756606-3756331 [Mycobacterium tuberculosis variant bovis AF2122/97]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT20560 NC_002945:c3756606-3756331 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References