Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2597596..2598588 | Replicon | chromosome |
| Accession | NZ_CP076382 | ||
| Organism | Mycobacterium intracellulare ATCC 13950 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | H8IK07 |
| Locus tag | KN251_RS12190 | Protein ID | WP_014380063.1 |
| Coordinates | 2598010..2598588 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | H8IK06 |
| Locus tag | KN251_RS12185 | Protein ID | WP_014380062.1 |
| Coordinates | 2597596..2597985 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KN251_RS12160 (KN251_12100) | 2593048..2595051 | + | 2004 | WP_009956386.1 | phosphotransferase | - |
| KN251_RS12165 (KN251_12105) | 2595048..2595593 | + | 546 | WP_044059213.1 | gluconokinase | - |
| KN251_RS12170 (KN251_12110) | 2595617..2596228 | - | 612 | WP_009956383.1 | TetR/AcrR family transcriptional regulator | - |
| KN251_RS12175 (KN251_12115) | 2596264..2597223 | + | 960 | WP_225331100.1 | SAM-dependent methyltransferase | - |
| KN251_RS12180 (KN251_12120) | 2597251..2597538 | + | 288 | WP_233425196.1 | hypothetical protein | - |
| KN251_RS12185 (KN251_12125) | 2597596..2597985 | + | 390 | WP_014380062.1 | hypothetical protein | Antitoxin |
| KN251_RS12190 (KN251_12130) | 2598010..2598588 | + | 579 | WP_014380063.1 | zeta toxin family protein | Toxin |
| KN251_RS12195 (KN251_12135) | 2598608..2599675 | - | 1068 | WP_014380064.1 | DoxX family protein | - |
| KN251_RS12200 (KN251_12140) | 2599771..2600331 | + | 561 | WP_014380065.1 | pyrazinamidase PncA | - |
| KN251_RS12205 (KN251_12145) | 2600331..2601131 | + | 801 | WP_014380066.1 | ketosteroid isomerase family protein | - |
| KN251_RS12210 (KN251_12150) | 2601143..2601493 | - | 351 | WP_041787061.1 | DoxX family protein | - |
| KN251_RS12215 (KN251_12155) | 2601659..2602630 | + | 972 | WP_014380069.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21017.13 Da Isoelectric Point: 11.0233
>T205598 WP_014380063.1 NZ_CP076382:2598010-2598588 [Mycobacterium intracellulare ATCC 13950]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD
Download Length: 579 bp
>T205598 NZ_CP101765:c238566-238096 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13572.99 Da Isoelectric Point: 5.1828
>AT205598 WP_014380062.1 NZ_CP076382:2597596-2597985 [Mycobacterium intracellulare ATCC 13950]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
FAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
FAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT205598 NZ_CP101765:c239006-238563 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7R7MTW2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7R7MVZ8 |