Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1139926..1140490 Replicon chromosome
Accession NZ_CP076382
Organism Mycobacterium intracellulare ATCC 13950

Toxin (Protein)


Gene name vapC Uniprot ID H8IVI4
Locus tag KN251_RS05700 Protein ID WP_009953437.1
Coordinates 1140119..1140490 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KN251_RS05695 Protein ID WP_026071432.1
Coordinates 1139926..1140132 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KN251_RS05675 (KN251_05655) 1135547..1136545 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
KN251_RS05680 (KN251_05660) 1136591..1137730 - 1140 WP_179293415.1 hypothetical protein -
KN251_RS05685 (KN251_05665) 1137872..1138945 + 1074 WP_009953440.1 redox-regulated ATPase YchF -
KN251_RS05690 (KN251_05670) 1139025..1139687 - 663 WP_014379386.1 methyltransferase domain-containing protein -
KN251_RS05695 (KN251_05675) 1139926..1140132 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KN251_RS05700 (KN251_05680) 1140119..1140490 + 372 WP_009953437.1 type II toxin-antitoxin system VapC family toxin Toxin
KN251_RS05705 (KN251_05685) 1140548..1141099 + 552 WP_009953436.1 VOC family protein -
KN251_RS05710 (KN251_05690) 1141178..1141576 + 399 WP_009953435.1 VOC family protein -
KN251_RS05715 (KN251_05695) 1141675..1142058 + 384 WP_026071433.1 hypothetical protein -
KN251_RS05720 (KN251_05700) 1142144..1142503 + 360 WP_179293417.1 hypothetical protein -
KN251_RS05725 1142628..1143056 + 429 Protein_1121 hypothetical protein -
KN251_RS05730 (KN251_05710) 1143623..1143946 + 324 WP_009953431.1 putative quinol monooxygenase -
KN251_RS05735 (KN251_05715) 1143995..1144678 - 684 WP_014384004.1 hypothetical protein -
KN251_RS05740 (KN251_05720) 1144825..1145034 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13868.20 Da        Isoelectric Point: 6.8398

>T205596 WP_009953437.1 NZ_CP076382:1140119-1140490 [Mycobacterium intracellulare ATCC 13950]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Download         Length: 372 bp

>T205596 NZ_CP101765:c93585-93436 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT205596 WP_026071432.1 NZ_CP076382:1139926-1140132 [Mycobacterium intracellulare ATCC 13950]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT205596 NZ_CP101765:93630-93689 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7R7MQX9

Antitoxin

Source ID Structure

References