Detailed information of TA system TA205592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1139088..1139652
• Replicon: chromosome
• Accession: NZ_CP076381
• Organism: Mycobacterium intracellulare strain S1-36A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD68
• Locus tag: KN247_RS05705
• Protein ID: WP_014941408.1
• Coordinates: 1139281..1139652 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN247_RS05700
• Protein ID: WP_036458377.1
• Coordinates: 1139088..1139294 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN247_RS05680 (KN247_05650)	1134704..1135702	+	999	WP_233042431.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
KN247_RS05685 (KN247_05655)	1135747..1136892	-	1146	WP_248913544.1	hypothetical protein	-
KN247_RS05690 (KN247_05660)	1137034..1138107	+	1074	WP_036458307.1	redox-regulated ATPase YchF	-
KN247_RS05695 (KN247_05665)	1138187..1138849	-	663	WP_036458309.1	methyltransferase domain-containing protein	-
KN247_RS05700 (KN247_05670)	1139088..1139294	+	207	WP_036458377.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KN247_RS05705 (KN247_05675)	1139281..1139652	+	372	WP_014941408.1	type II toxin-antitoxin system VapC family toxin	Toxin
KN247_RS05710 (KN247_05680)	1139710..1140261	+	552	WP_038535279.1	VOC family protein	-
KN247_RS05715 (KN247_05685)	1140340..1140738	+	399	WP_009953435.1	VOC family protein	-
KN247_RS05720 (KN247_05690)	1140885..1141220	+	336	WP_014379387.1	hypothetical protein	-
KN247_RS05725 (KN247_05695)	1141306..1141665	+	360	WP_179960061.1	hypothetical protein	-
KN247_RS05730	1141790..1142218	+	429	Protein_1126	hypothetical protein	-
KN247_RS05735 (KN247_05705)	1142785..1143108	+	324	WP_009953431.1	putative quinol monooxygenase	-
KN247_RS05740 (KN247_05710)	1143157..1143840	-	684	WP_014384004.1	hypothetical protein	-
KN247_RS05745 (KN247_05715)	1143987..1144196	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T205592 WP_014941408.1 NZ_CP076381:1139281-1139652 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSQLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T205592 NZ_CP101764:c4739984-4739451 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7220.29 Da
• Isoelectric Point: 11.9169

>AT205592 WP_036458377.1 NZ_CP076381:1139088-1139294 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVAESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT205592 NZ_CP101764:c4740261-4739995 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: J9WD68