Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3728712..3729241 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | BQ2027_RS17320 | Protein ID | WP_003417760.1 |
| Coordinates | 3728984..3729241 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | BQ2027_RS17315 | Protein ID | WP_003417757.1 |
| Coordinates | 3728712..3728987 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS20550 (BQ2027_MB3386C) | 3725285..3725974 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| BQ2027_RS20555 (BQ2027_MB3387C) | 3726161..3726532 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| BQ2027_RS20560 | 3726430..3726648 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| BQ2027_RS20565 (BQ2027_MB3388C) | 3726675..3726935 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| BQ2027_RS17300 (BQ2027_MB3389) | 3727050..3727439 | + | 390 | WP_010950876.1 | DUF732 domain-containing protein | - |
| BQ2027_RS17305 (BQ2027_MB3390C) | 3727453..3727746 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| BQ2027_RS17310 (BQ2027_MB3391C) | 3727743..3728588 | - | 846 | WP_010950877.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| BQ2027_RS17315 (BQ2027_MB3392) | 3728712..3728987 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| BQ2027_RS17320 (BQ2027_MB3393) | 3728984..3729241 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| BQ2027_RS17325 (BQ2027_MB3394) | 3729283..3730473 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| BQ2027_RS17330 (BQ2027_MB3395) | 3730590..3730958 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| BQ2027_RS17335 (BQ2027_MB3396C) | 3730955..3731506 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| BQ2027_RS17340 (BQ2027_MB3397C) | 3731513..3732094 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| BQ2027_RS17345 (BQ2027_MB3398C) | 3732075..3732443 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| BQ2027_RS17350 (BQ2027_MB3399C) | 3732421..3732813 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T20559 WP_003417760.1 NC_002945:3728984-3729241 [Mycobacterium tuberculosis variant bovis AF2122/97]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T20559 NC_002945:3728984-3729241 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT20559 WP_003417757.1 NC_002945:3728712-3728987 [Mycobacterium tuberculosis variant bovis AF2122/97]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT20559 NC_002945:3728712-3728987 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|