Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1139434..1139998 Replicon chromosome
Accession NZ_CP076380
Organism Mycobacterium intracellulare strain S1-32

Toxin (Protein)


Gene name vapC Uniprot ID H8IVI4
Locus tag KN246_RS05725 Protein ID WP_009953437.1
Coordinates 1139627..1139998 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KN246_RS05720 Protein ID WP_026071432.1
Coordinates 1139434..1139640 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KN246_RS05700 (KN246_05665) 1135055..1136053 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
KN246_RS05705 (KN246_05670) 1136099..1137238 - 1140 WP_179300624.1 hypothetical protein -
KN246_RS05710 (KN246_05675) 1137380..1138453 + 1074 WP_009953440.1 redox-regulated ATPase YchF -
KN246_RS05715 (KN246_05680) 1138533..1139195 - 663 WP_014379386.1 methyltransferase domain-containing protein -
KN246_RS05720 (KN246_05685) 1139434..1139640 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KN246_RS05725 (KN246_05690) 1139627..1139998 + 372 WP_009953437.1 type II toxin-antitoxin system VapC family toxin Toxin
KN246_RS05730 (KN246_05695) 1140056..1140607 + 552 WP_009953436.1 VOC family protein -
KN246_RS05735 (KN246_05700) 1140686..1141084 + 399 WP_009953435.1 VOC family protein -
KN246_RS05740 (KN246_05705) 1141183..1141566 + 384 WP_026071433.1 hypothetical protein -
KN246_RS05745 (KN246_05710) 1141652..1142011 + 360 WP_198139476.1 hypothetical protein -
KN246_RS05750 1142136..1142564 + 429 Protein_1126 hypothetical protein -
KN246_RS05755 (KN246_05720) 1143131..1143454 + 324 WP_009953431.1 putative quinol monooxygenase -
KN246_RS05760 (KN246_05725) 1143503..1144186 - 684 WP_014384004.1 hypothetical protein -
KN246_RS05765 (KN246_05730) 1144333..1144542 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13868.20 Da        Isoelectric Point: 6.8398

>T205588 WP_009953437.1 NZ_CP076380:1139627-1139998 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Download         Length: 372 bp

>T205588 NZ_CP101764:2008507-2008609 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT205588 WP_026071432.1 NZ_CP076380:1139434-1139640 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT205588 NZ_CP101764:c2008616-2008471 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7R7MQX9

Antitoxin

Source ID Structure

References