Detailed information of TA system TA205586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2629329..2630321
• Replicon: chromosome
• Accession: NZ_CP076379
• Organism: Mycobacterium intracellulare strain S2-11

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: KN252_RS12290
• Protein ID: WP_038536181.1
• Coordinates: 2629743..2630321 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: X8A634
• Locus tag: KN252_RS12285
• Protein ID: WP_038536179.1
• Coordinates: 2629329..2629718 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN252_RS12260 (KN252_12200)	2624780..2626783	+	2004	WP_095562692.1	phosphotransferase	-
KN252_RS12265 (KN252_12205)	2626780..2627280	+	501	WP_038536171.1	gluconokinase	-
KN252_RS12270 (KN252_12210)	2627351..2627962	-	612	WP_095562693.1	TetR/AcrR family transcriptional regulator	-
KN252_RS12275 (KN252_12215)	2627998..2628957	+	960	WP_225331100.1	SAM-dependent methyltransferase	-
KN252_RS12280 (KN252_12220)	2628985..2629272	+	288	WP_014941865.1	hypothetical protein	-
KN252_RS12285 (KN252_12225)	2629329..2629718	+	390	WP_038536179.1	hypothetical protein	Antitoxin
KN252_RS12290 (KN252_12230)	2629743..2630321	+	579	WP_038536181.1	zeta toxin family protein	Toxin
KN252_RS12295 (KN252_12235)	2630341..2631408	-	1068	WP_038536184.1	DoxX family protein	-
KN252_RS12300 (KN252_12240)	2631504..2632064	+	561	WP_042911761.1	pyrazinamidase PncA	-
KN252_RS12305 (KN252_12245)	2632064..2632864	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
KN252_RS12310 (KN252_12250)	2632876..2633226	-	351	WP_020188920.1	DoxX family protein	-
KN252_RS12315 (KN252_12255)	2633392..2634363	+	972	WP_014382494.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21103.22 Da
• Isoelectric Point: 11.0233

>T205586 WP_038536181.1 NZ_CP076379:2629743-2630321 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIPFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T205586 NZ_CP101764:746626-747111 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13507.88 Da
• Isoelectric Point: 5.5186

>AT205586 WP_038536179.1 NZ_CP076379:2629329-2629718 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGHLATGELTVEEGVVFNAEI
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT205586 NZ_CP101764:746336-746629 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: X8A634