Detailed information of TA system TA205585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1231359..1231923
• Replicon: chromosome
• Accession: NZ_CP076379
• Organism: Mycobacterium intracellulare strain S2-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KN252_RS06110
• Protein ID: WP_041784823.1
• Coordinates: 1231552..1231923 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN252_RS06105
• Protein ID: WP_026071432.1
• Coordinates: 1231359..1231565 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN252_RS06085 (KN252_06065)	1226974..1227972	+	999	WP_248923539.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
KN252_RS06090 (KN252_06070)	1228018..1229163	-	1146	WP_248923540.1	hypothetical protein	-
KN252_RS06095 (KN252_06075)	1229305..1230378	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
KN252_RS06100 (KN252_06080)	1230458..1231120	-	663	WP_248923661.1	methyltransferase domain-containing protein	-
KN252_RS06105 (KN252_06085)	1231359..1231565	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KN252_RS06110 (KN252_06090)	1231552..1231923	+	372	WP_041784823.1	type II toxin-antitoxin system VapC family toxin	Toxin
KN252_RS06115 (KN252_06095)	1231982..1232532	+	551	Protein_1200	VOC family protein	-
KN252_RS06120 (KN252_06100)	1232611..1233009	+	399	WP_009953435.1	VOC family protein	-
KN252_RS06125 (KN252_06105)	1233109..1233492	+	384	WP_026071433.1	hypothetical protein	-
KN252_RS06130 (KN252_06110)	1233576..1233935	+	360	WP_248923541.1	hypothetical protein	-
KN252_RS06135	1234060..1234488	+	429	Protein_1204	hypothetical protein	-
KN252_RS06140 (KN252_06120)	1235055..1235378	+	324	WP_009953431.1	putative quinol monooxygenase	-
KN252_RS06145 (KN252_06125)	1235427..1236110	-	684	WP_014384004.1	hypothetical protein	-
KN252_RS06150 (KN252_06130)	1236257..1236466	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13877.21 Da
• Isoelectric Point: 6.9118

>T205585 WP_041784823.1 NZ_CP076379:1231552-1231923 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T205585 NZ_CP101764:354089-354436 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT205585 WP_026071432.1 NZ_CP076379:1231359-1231565 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT205585 NZ_CP101764:354436-354735 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA