Detailed information of TA system TA205581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3207702..3208366
• Replicon: chromosome
• Accession: NZ_CP076378
• Organism: Mycobacterium intracellulare strain S2-8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IUS5
• Locus tag: KN249_RS15205
• Protein ID: WP_014379897.1
• Coordinates: 3207702..3208109 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KN249_RS15210
• Protein ID: WP_009954496.1
• Coordinates: 3208106..3208366 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN249_RS15195 (KN249_15155)	3202797..3204362	+	1566	WP_014379899.1	serine/threonine-protein kinase	-
KN249_RS15200 (KN249_15160)	3204423..3207524	-	3102	WP_014379898.1	DEAD/DEAH box helicase	-
KN249_RS15205 (KN249_15165)	3207702..3208109	-	408	WP_014379897.1	type II toxin-antitoxin system VapC family toxin	Toxin
KN249_RS15210 (KN249_15170)	3208106..3208366	-	261	WP_009954496.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KN249_RS15215 (KN249_15175)	3208539..3208745	-	207	WP_225331375.1	hypothetical protein	-
KN249_RS15220 (KN249_15180)	3208809..3209261	-	453	WP_014379896.1	VOC family protein	-
KN249_RS15225 (KN249_15185)	3209419..3210687	+	1269	WP_014379895.1	cytochrome P450	-
KN249_RS15230 (KN249_15190)	3210692..3211288	-	597	WP_009954492.1	TetR/AcrR family transcriptional regulator	-
KN249_RS15235 (KN249_15195)	3211358..3211849	+	492	WP_014379893.1	DUF1707 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14307.31 Da
• Isoelectric Point: 4.2772

>T205581 WP_014379897.1 NZ_CP076378:c3208109-3207702 [Mycobacterium intracellulare]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPIDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T205581 NZ_CP101752:5933813-5934067 [Pseudomonas citronellolis]
ATGAATAGCCGGCAGCGGGCGACCCTGGAAGCGCTCTACGCGGTCCCTACGCCATGCAACCTGGAATGGGCACGCATTGA
ATCCCTGCTGCTCTCGCTGGGCGCCAGGCTTATCGAAGGCAACGGCTCGCGCGTGCGCTTCGAGCTGAATGGCGTCATCG
CCAGCTTCCACCGCCCGCACCCGGCCAAGGAAGCCAAACCCTATCAGGTCCGCGATGCGCGGGCCTTCATCGAACGAGCG
GGATACGCACCATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9526.85 Da
• Isoelectric Point: 9.1203

>AT205581 WP_009954496.1 NZ_CP076378:c3208366-3208106 [Mycobacterium intracellulare]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Nucleotide

• Length: 261 bp

>AT205581 NZ_CP101752:5934064-5934390 [Pseudomonas citronellolis]
ATGAGCCCGATGAAATACAAAGGCTATGTCGCACGCATCGAGTACAGCGACGACGACGGGCTGTTCATCGGCCATATCGC
CGGCATCCAGGACGTCATCGGTTTCCATGGCGAGTCGGTGAGCGAACTGCGCCAGTTGTTCCATGAGGCCGTCGACGACT
ACCTCGACACCTGCGCCAAGCTCGGCCGCGAGCCACAGAAGCCCTACTCCGGCAAGCTCAGCCTGCGCCTGGACCCGGCA
CTGCATGCCCGCGTCGCGCTCAAGGCGGAGCTGAGCAACAAGAGCATCAACCAGTGGGTGGCGGAGCGGCTGAGCGAAGC
GGTGTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MTD0