Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RHH |
| Location | 18329..18906 | Replicon | plasmid p6 |
| Accession | NZ_CP076367 | ||
| Organism | Gemmobacter fulva strain con5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | KM031_RS22560 | Protein ID | WP_215507548.1 |
| Coordinates | 18329..18637 (-) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | KM031_RS22565 | Protein ID | WP_215507551.1 |
| Coordinates | 18634..18906 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KM031_RS22545 (KM031_22450) | 13932..15281 | - | 1350 | WP_215507543.1 | HipA domain-containing protein | - |
| KM031_RS22550 (KM031_22455) | 15284..15496 | - | 213 | WP_215507545.1 | helix-turn-helix domain-containing protein | - |
| KM031_RS22555 (KM031_22460) | 15768..18044 | - | 2277 | WP_215507547.1 | calcium-binding protein | - |
| KM031_RS22560 (KM031_22465) | 18329..18637 | - | 309 | WP_215507548.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KM031_RS22565 (KM031_22470) | 18634..18906 | - | 273 | WP_215507551.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| KM031_RS22570 (KM031_22475) | 19136..19534 | + | 399 | WP_215507553.1 | helix-turn-helix transcriptional regulator | - |
| KM031_RS22575 (KM031_22480) | 19531..19713 | + | 183 | WP_215507555.1 | hypothetical protein | - |
| KM031_RS22580 (KM031_22485) | 20011..21045 | + | 1035 | WP_215507557.1 | replication initiator protein A | - |
| KM031_RS22585 (KM031_22490) | 21344..22024 | - | 681 | WP_215507558.1 | recombinase family protein | - |
| KM031_RS22590 (KM031_22495) | 22472..23086 | + | 615 | WP_215507559.1 | ParA family protein | - |
| KM031_RS22595 (KM031_22500) | 23079..23345 | + | 267 | WP_215507560.1 | CopG family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..33980 | 33980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11196.98 Da Isoelectric Point: 7.2018
>T205547 WP_215507548.1 NZ_CP076367:c18637-18329 [Gemmobacter fulva]
MKRLVIAEPAARDLEGIVNYIALDNPAAAETVYRGIVETARKLPQFPALGRPGRHPETREMSVSGLPYLIVYEVGAETVT
ILAVFHTARDLAQALRERLIAS
MKRLVIAEPAARDLEGIVNYIALDNPAAAETVYRGIVETARKLPQFPALGRPGRHPETREMSVSGLPYLIVYEVGAETVT
ILAVFHTARDLAQALRERLIAS
Download Length: 309 bp
>T205547 NZ_CP101727:45388-45537 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10113.59 Da Isoelectric Point: 8.6094
>AT205547 WP_215507551.1 NZ_CP076367:c18906-18634 [Gemmobacter fulva]
MITKDHKMPQRPTTEPITIRTAKVQEIDALAHAMDRSRNYIVNQAIEQYLEANVWQMERISAGIAAAREGKVLPADDVFA
AIAAKHGWSR
MITKDHKMPQRPTTEPITIRTAKVQEIDALAHAMDRSRNYIVNQAIEQYLEANVWQMERISAGIAAAREGKVLPADDVFA
AIAAKHGWSR
Download Length: 273 bp
>AT205547 NZ_CP101727:c45343-45284 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|