Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 58056..58683 Replicon plasmid p4
Accession NZ_CP076365
Organism Gemmobacter fulva strain con5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KM031_RS21185 Protein ID WP_215507927.1
Coordinates 58273..58683 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KM031_RS21180 Protein ID WP_215507926.1
Coordinates 58056..58283 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM031_RS21165 (KM031_21110) 54313..55524 - 1212 WP_215507929.1 plasmid replication protein RepC -
KM031_RS21170 (KM031_21115) 55737..56669 - 933 WP_215507924.1 plasmid partitioning protein RepB -
KM031_RS21175 (KM031_21120) 56653..57846 - 1194 WP_010400282.1 plasmid partitioning protein RepA -
KM031_RS21180 (KM031_21125) 58056..58283 + 228 WP_215507926.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KM031_RS21185 (KM031_21130) 58273..58683 + 411 WP_215507927.1 PIN domain-containing protein Toxin
KM031_RS21190 (KM031_21135) 58793..59902 - 1110 WP_018001705.1 tyrosine-type recombinase/integrase -
KM031_RS21195 (KM031_21140) 60017..60907 + 891 WP_215507973.1 DUF1403 family protein -
KM031_RS21200 (KM031_21145) 60910..61518 + 609 WP_215507975.1 SMC-Scp complex subunit ScpB -
KM031_RS21205 (KM031_21150) 61515..62558 - 1044 WP_215507977.1 TniQ family protein -
KM031_RS21210 (KM031_21155) 62555..63436 - 882 WP_215507979.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..193372 193372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14808.83 Da        Isoelectric Point: 4.1964

>T205546 WP_215507927.1 NZ_CP076365:58273-58683 [Gemmobacter fulva]
MSAEFADTNVVLYLLDDGSKADRAEVILGQGPRISVQVLNETLVNCRRKAGLSWEEAGAFLEGVRALCPVEDLTLQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIINPFARADSF

Download         Length: 411 bp

>T205546 NZ_CP101726:c5382111-5381728 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8588.85 Da        Isoelectric Point: 10.7157

>AT205546 WP_215507926.1 NZ_CP076365:58056-58283 [Gemmobacter fulva]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDRQVRVRRLARADEVLTGLRQFRGKLPAAERLSRDDAHER

Download         Length: 228 bp

>AT205546 NZ_CP101726:c5382353-5382111 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References