Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 4372..4979 Replicon plasmid p3
Accession NZ_CP076364
Organism Gemmobacter fulva strain con5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KM031_RS20000 Protein ID WP_215507129.1
Coordinates 4728..4979 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KM031_RS19995 Protein ID WP_215507127.1
Coordinates 4372..4716 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM031_RS19970 (KM031_19940) 1261..1617 - 357 WP_215507117.1 hypothetical protein -
KM031_RS19975 (KM031_19945) 1882..2787 + 906 WP_215507119.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
KM031_RS19980 2977..3229 - 253 Protein_3 type II toxin-antitoxin system RelE/ParE family toxin -
KM031_RS19985 (KM031_19955) 3226..3507 - 282 WP_215507123.1 type II toxin-antitoxin system ParD family antitoxin -
KM031_RS19990 (KM031_19960) 3591..4145 - 555 WP_215507125.1 excalibur calcium-binding domain-containing protein -
KM031_RS19995 (KM031_19965) 4372..4716 - 345 WP_215507127.1 helix-turn-helix transcriptional regulator Antitoxin
KM031_RS20000 (KM031_19970) 4728..4979 - 252 WP_215507129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KM031_RS20005 (KM031_19975) 5070..5702 - 633 WP_215507130.1 tyrosine-type recombinase/integrase -
KM031_RS20010 (KM031_19980) 6040..7158 + 1119 WP_215507133.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..196089 196089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-79)

Antitoxin

Cro/C1-type helix-turn-helix domain

(58-112)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9180.63 Da        Isoelectric Point: 10.8825

>T205545 WP_215507129.1 NZ_CP076364:c4979-4728 [Gemmobacter fulva]
MKQISYTKAAIRALRRMPANTAVLIRSKIEAYAQDPASQGNNLRALKGREGIRLRVGDWRVVMDDQGNVLAVLDIGPRGG
IYD

Download         Length: 252 bp

>T205545 NZ_CP101726:c5058560-5057643 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12474.92 Da        Isoelectric Point: 4.2527

>AT205545 WP_215507127.1 NZ_CP076364:c4716-4372 [Gemmobacter fulva]
MNEMVTIPREEYDRLRAAAEDLADLQSYDRAKAALGAGGDELIPSDYANRLLDGENPLRVYRDLRGLTQATLAERADVNR
VTVAEIETGRKQGSIATLRALAGALDITLDDLTE

Download         Length: 345 bp

>AT205545 NZ_CP101726:c5059324-5058566 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References