Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3748577..3749231 Replicon chromosome
Accession NZ_CP076344
Organism Escherichia coli strain AVS0096

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag KM937_RS18050 Protein ID WP_000244781.1
Coordinates 3748577..3748984 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KM937_RS18055 Protein ID WP_000354046.1
Coordinates 3748965..3749231 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM937_RS18030 (3744534) 3744534..3746267 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
KM937_RS18035 (3746273) 3746273..3746983 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KM937_RS18040 (3747008) 3747008..3747904 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KM937_RS18045 (3748016) 3748016..3748537 + 522 WP_001055874.1 flavodoxin FldB -
KM937_RS18050 (3748577) 3748577..3748984 - 408 WP_000244781.1 protein YgfX Toxin
KM937_RS18055 (3748965) 3748965..3749231 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KM937_RS18060 (3749474) 3749474..3750454 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
KM937_RS18065 (3750531) 3750531..3751190 - 660 WP_000250274.1 hemolysin III family protein -
KM937_RS18070 (3751354) 3751354..3751665 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
KM937_RS18075 (3751710) 3751710..3753143 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T205536 WP_000244781.1 NZ_CP076344:c3748984-3748577 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T205536 NZ_CP101719:c4263141-4262989 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT205536 WP_000354046.1 NZ_CP076344:c3749231-3748965 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT205536 NZ_CP101719:c4262914-4262780 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References