Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3071131..3071701 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P71650 |
| Locus tag | BQ2027_RS14400 | Protein ID | WP_003414166.1 |
| Coordinates | 3071131..3071487 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL61 |
| Locus tag | BQ2027_RS14405 | Protein ID | WP_003901465.1 |
| Coordinates | 3071471..3071701 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS14380 (BQ2027_MB2820C) | 3066580..3068268 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
| BQ2027_RS14385 (BQ2027_MB2821C) | 3068272..3068598 | - | 327 | WP_003414157.1 | hypothetical protein | - |
| BQ2027_RS14390 (BQ2027_MB2822) | 3068771..3069361 | + | 591 | WP_031656198.1 | DUF3558 family protein | - |
| BQ2027_RS14395 (BQ2027_MB2823) | 3069380..3071029 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
| BQ2027_RS14400 (BQ2027_MB2824C) | 3071131..3071487 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
| BQ2027_RS14405 (BQ2027_MB2824A) | 3071471..3071701 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
| BQ2027_RS14410 (BQ2027_MB2825C) | 3071744..3072787 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
| BQ2027_RS20490 (BQ2027_MB2826) | 3072786..3073253 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
| BQ2027_RS14420 | 3073429..3073683 | - | 255 | WP_003917684.1 | hypothetical protein | - |
| BQ2027_RS14425 (BQ2027_MB2828) | 3073831..3074235 | + | 405 | WP_003414181.1 | hypothetical protein | - |
| BQ2027_RS14430 (BQ2027_MB2829) | 3074232..3074423 | + | 192 | WP_003414184.1 | hypothetical protein | - |
| BQ2027_RS20495 | 3074640..3074900 | + | 261 | Protein_2885 | transposase | - |
| BQ2027_RS14440 (BQ2027_MB2831) | 3076010..3076267 | + | 258 | WP_003899489.1 | hypothetical protein | - |
| BQ2027_RS14445 (BQ2027_MB2832) | 3076372..3076683 | + | 312 | WP_010950777.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T20552 WP_003414166.1 NC_002945:c3071487-3071131 [Mycobacterium tuberculosis variant bovis AF2122/97]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T20552 NC_002945:c3071487-3071131 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT20552 WP_003901465.1 NC_002945:c3071701-3071471 [Mycobacterium tuberculosis variant bovis AF2122/97]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT20552 NC_002945:c3071701-3071471 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|