Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
| Location | 3980855..3981431 | Replicon | chromosome |
| Accession | NZ_CP076318 | ||
| Organism | Escherichia coli strain Survcare045 | ||
Toxin (Protein)
| Gene name | shpA | Uniprot ID | D3GXZ2 |
| Locus tag | KNN08_RS20765 | Protein ID | WP_001297643.1 |
| Coordinates | 3980855..3981142 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | shpB | Uniprot ID | A0A080I7H7 |
| Locus tag | KNN08_RS20770 | Protein ID | WP_000063160.1 |
| Coordinates | 3981129..3981431 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KNN08_RS20750 (3977092) | 3977092..3978372 | - | 1281 | WP_001037390.1 | DUF445 domain-containing protein | - |
| KNN08_RS20755 (3978413) | 3978413..3979645 | - | 1233 | WP_001137030.1 | multidrug efflux MFS transporter MdtM | - |
| KNN08_RS20760 (3979960) | 3979960..3980656 | + | 697 | Protein_3759 | IS1 family transposase | - |
| KNN08_RS20765 (3980855) | 3980855..3981142 | + | 288 | WP_001297643.1 | BrnT family toxin | Toxin |
| KNN08_RS20770 (3981129) | 3981129..3981431 | + | 303 | WP_000063160.1 | BrnA antitoxin family protein | Antitoxin |
| KNN08_RS20775 (3981465) | 3981465..3982421 | - | 957 | WP_001297640.1 | GTPase | - |
| KNN08_RS20780 (3982432) | 3982432..3982635 | - | 204 | WP_000467859.1 | YbdD/YjiX family protein | - |
| KNN08_RS20785 (3982685) | 3982685..3984835 | - | 2151 | WP_001295524.1 | pyruvate/proton symporter BtsT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3980447..3980656 | 209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11295.77 Da Isoelectric Point: 6.8821
>T205508 WP_001297643.1 NZ_CP076318:3980855-3981142 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
>T205508 NZ_CP101704:c4862303-4862169 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11552.01 Da Isoelectric Point: 9.4646
>AT205508 WP_000063160.1 NZ_CP076318:3981129-3981431 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT205508 NZ_CP101704:c4862519-4862367 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829GEV9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A080I7H7 |