Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3031156..3031835 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | BQ2027_RS14180 | Protein ID | WP_003414059.1 |
| Coordinates | 3031156..3031572 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | BQ2027_RS14185 | Protein ID | WP_003414061.1 |
| Coordinates | 3031569..3031835 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS14160 (BQ2027_MB2774C) | 3027208..3028110 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| BQ2027_RS14165 (BQ2027_MB2775C) | 3028179..3028931 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| BQ2027_RS14170 (BQ2027_MB2776C) | 3029175..3029450 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| BQ2027_RS14175 (BQ2027_MB2777C) | 3029447..3031069 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| BQ2027_RS14180 (BQ2027_MB2778C) | 3031156..3031572 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| BQ2027_RS14185 (BQ2027_MB2779C) | 3031569..3031835 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| BQ2027_RS14190 (BQ2027_MB2780C) | 3031861..3032256 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| BQ2027_RS14195 (BQ2027_MB2781C) | 3032253..3032522 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| BQ2027_RS14200 (BQ2027_MB2782C) | 3032532..3033626 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| BQ2027_RS14205 (BQ2027_MB2783C) | 3033623..3034042 | - | 420 | Protein_2837 | winged helix-turn-helix domain-containing protein | - |
| BQ2027_RS20480 | 3034041..3034115 | + | 75 | Protein_2838 | hypothetical protein | - |
| BQ2027_RS14210 (BQ2027_MB2785C) | 3034116..3034595 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| BQ2027_RS14215 (BQ2027_MB2786C) | 3034666..3035466 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| BQ2027_RS14220 (BQ2027_MB2787) | 3035622..3036359 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T20550 WP_003414059.1 NC_002945:c3031572-3031156 [Mycobacterium tuberculosis variant bovis AF2122/97]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T20550 NC_002945:c3031572-3031156 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT20550 WP_003414061.1 NC_002945:c3031835-3031569 [Mycobacterium tuberculosis variant bovis AF2122/97]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT20550 NC_002945:c3031835-3031569 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|