Detailed information of TA system TA205489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 779535..780173
• Replicon: chromosome
• Accession: NZ_CP076318
• Organism: Escherichia coli strain Survcare045

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: KNN08_RS05495
• Protein ID: WP_001447010.1
• Coordinates: 779535..779711 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KNN08_RS05500
• Protein ID: WP_001270286.1
• Coordinates: 779757..780173 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNN08_RS05475 (775154)	775154..776329	-	1176	WP_001236265.1	BenE family transporter YdcO	-
KNN08_RS05480 (776421)	776421..776957	+	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
KNN08_RS05485 (777030)	777030..778991	+	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
KNN08_RS05490 (779083)	779083..779313	-	231	WP_000494244.1	YncJ family protein	-
KNN08_RS05495 (779535)	779535..779711	+	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
KNN08_RS05500 (779757)	779757..780173	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
KNN08_RS05505 (780252)	780252..781658	+	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
KNN08_RS05510 (781903)	781903..783048	+	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
KNN08_RS05515 (783066)	783066..784079	+	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
KNN08_RS05520 (784080)	784080..785021	+	942	WP_001251304.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T205489 WP_001447010.1 NZ_CP076318:779535-779711 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T205489 NZ_CP101689:c4826129-4825845 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT205489 WP_001270286.1 NZ_CP076318:779757-780173 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT205489 NZ_CP101689:c4826367-4826119 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8