Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2841591..2842228 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P0DMV7 |
| Locus tag | BQ2027_RS13165 | Protein ID | WP_003413180.1 |
| Coordinates | 2841591..2841986 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ44 |
| Locus tag | BQ2027_RS13170 | Protein ID | WP_003413183.1 |
| Coordinates | 2841983..2842228 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS13125 (BQ2027_MB2572) | 2837676..2838335 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| BQ2027_RS13130 (BQ2027_MB2573) | 2838332..2838991 | + | 660 | WP_003900847.1 | LppA family lipoprotein | - |
| BQ2027_RS13135 (BQ2027_MB2574) | 2838988..2839650 | + | 663 | WP_003900848.1 | LppA family lipoprotein | - |
| BQ2027_RS13140 (BQ2027_MB2575) | 2839647..2839925 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| BQ2027_RS13145 (BQ2027_MB2576) | 2840018..2840431 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| BQ2027_RS13150 (BQ2027_MB2577) | 2840470..2840727 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | - |
| BQ2027_RS13155 (BQ2027_MB2578) | 2840724..2841101 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| BQ2027_RS13160 (BQ2027_MB2578A) | 2841117..2841491 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| BQ2027_RS13165 (BQ2027_MB2579C) | 2841591..2841986 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
| BQ2027_RS13170 (BQ2027_MB2580C) | 2841983..2842228 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
| BQ2027_RS13175 (BQ2027_MB2581C) | 2842639..2843058 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| BQ2027_RS13180 (BQ2027_MB2582C) | 2843070..2843878 | - | 809 | Protein_2636 | shikimate dehydrogenase | - |
| BQ2027_RS13185 (BQ2027_MB2583C) | 2843875..2845128 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| BQ2027_RS13190 (BQ2027_MB2584C) | 2845121..2845633 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T20548 WP_003413180.1 NC_002945:c2841986-2841591 [Mycobacterium tuberculosis variant bovis AF2122/97]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
>T20548 NC_002945:c2841986-2841591 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 9098.33 Da Isoelectric Point: 5.6007
>AT20548 WP_003413183.1 NC_002945:c2842228-2841983 [Mycobacterium tuberculosis variant bovis AF2122/97]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
Download Length: 246 bp
>AT20548 NC_002945:c2842228-2841983 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 5WZ4 | |
| PDB | 5WZF |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BW31 |