20544

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2779291..2779943 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag BQ2027_RS12860 Protein ID WP_003412752.1
Coordinates 2779518..2779943 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag BQ2027_RS12855 Protein ID WP_003412749.1
Coordinates 2779291..2779512 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS12840 2777531..2777737 - 207 WP_003899347.1 hypothetical protein -
BQ2027_RS12845 (BQ2027_MB2519) 2777873..2778496 + 624 WP_003900858.1 TIGR00725 family protein -
BQ2027_RS12850 (BQ2027_MB2520) 2778486..2779238 + 753 WP_003901416.1 hypothetical protein -
BQ2027_RS12855 (BQ2027_MB2521) 2779291..2779512 + 222 WP_003412749.1 antitoxin Antitoxin
BQ2027_RS12860 (BQ2027_MB2522) 2779518..2779943 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ2027_RS12865 (BQ2027_MB2523C) 2779966..2781147 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
BQ2027_RS12870 (BQ2027_MB2524C) 2781144..2782190 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
BQ2027_RS12875 (BQ2027_MB2525C) 2782201..2783304 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
BQ2027_RS12880 (BQ2027_MB2526C) 2783563..2784384 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
BQ2027_RS12885 (BQ2027_MB2527C) 2784381..2784938 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T20544 WP_003412752.1 NC_002945:2779518-2779943 [Mycobacterium tuberculosis variant bovis AF2122/97]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T20544 NC_002945:2779518-2779943 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT20544 WP_003412749.1 NC_002945:2779291-2779512 [Mycobacterium tuberculosis variant bovis AF2122/97]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT20544 NC_002945:2779291-2779512 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References