Detailed information of TA system TA205435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 5019292..5019997
• Replicon: chromosome
• Accession: NZ_CP076301
• Organism: Escherichia coli strain Survcare321

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: KNN06_RS23930
• Protein ID: WP_000539521.1
• Coordinates: 5019611..5019997 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KNN06_RS23925
• Protein ID: WP_001280945.1
• Coordinates: 5019292..5019621 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNN06_RS23910 (5014449)	5014449..5015360	+	912	WP_001236019.1	glutathione ABC transporter permease GsiD	-
KNN06_RS23915 (5015538)	5015538..5017886	+	2349	WP_021523051.1	EAL domain-containing protein	-
KNN06_RS23920 (5017894)	5017894..5019222	+	1329	WP_000086873.1	GGDEF domain-containing protein	-
KNN06_RS23925 (5019292)	5019292..5019621	-	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
KNN06_RS23930 (5019611)	5019611..5019997	-	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KNN06_RS23935 (5020223)	5020223..5021548	-	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
KNN06_RS23940 (5021761)	5021761..5022144	+	384	WP_000497137.1	biofilm formation regulator BssR	-
KNN06_RS23945 (5022255)	5022255..5023370	+	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
KNN06_RS23950 (5023367)	5023367..5023993	-	627	WP_020233670.1	glutathione S-transferase GstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T205435 WP_000539521.1 NZ_CP076301:c5019997-5019611 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T205435 NZ_CP101648:3975410-3975667 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT205435 WP_001280945.1 NZ_CP076301:c5019621-5019292 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT205435 NZ_CP101648:c3975585-3975253 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A829GCT6