Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3988951..3989765 Replicon chromosome
Accession NZ_CP076301
Organism Escherichia coli strain Survcare321

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KNN06_RS19230 Protein ID WP_001054376.1
Coordinates 3989508..3989765 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag KNN06_RS19225 Protein ID WP_001309181.1
Coordinates 3988951..3989496 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNN06_RS19195 (3984642) 3984642..3985955 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
KNN06_RS19200 (3985967) 3985967..3986245 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KNN06_RS19205 (3986242) 3986242..3987363 - 1122 WP_000010829.1 M42 family metallopeptidase -
KNN06_RS19210 (3987608) 3987608..3987724 - 117 Protein_3778 VOC family protein -
KNN06_RS19215 (3987762) 3987762..3987980 - 219 Protein_3779 hypothetical protein -
KNN06_RS19220 (3988149) 3988149..3988895 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KNN06_RS19225 (3988951) 3988951..3989496 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
KNN06_RS19230 (3989508) 3989508..3989765 - 258 WP_001054376.1 YjhX family toxin Toxin
KNN06_RS26060 (3990256) 3990256..3990387 - 132 WP_001309182.1 hypothetical protein -
KNN06_RS19240 (3990503) 3990503..3991743 + 1241 Protein_3784 helicase YjhR -
KNN06_RS26065 (3992011) 3992011..3992216 - 206 Protein_3785 HNH endonuclease -
KNN06_RS19245 (3992326) 3992326..3993306 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KNN06_RS19250 (3993371) 3993371..3994477 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T205431 WP_001054376.1 NZ_CP076301:c3989765-3989508 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T205431 NZ_CP101648:c1394646-1394119 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGATTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT205431 WP_001309181.1 NZ_CP076301:c3989496-3988951 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT205431 NZ_CP101648:c1394933-1394643 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References