Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2401641..2402475 Replicon chromosome
Accession NZ_CP076301
Organism Escherichia coli strain Survcare321

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag KNN06_RS11670 Protein ID WP_000854689.1
Coordinates 2402098..2402475 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag KNN06_RS11665 Protein ID WP_001285599.1
Coordinates 2401641..2402021 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNN06_RS11630 (2397728) 2397728..2398183 + 456 WP_001309747.1 IrmA family protein -
KNN06_RS11635 (2398326) 2398326..2398415 + 90 WP_225385657.1 DUF905 family protein -
KNN06_RS11640 (2398594) 2398594..2399415 + 822 WP_099004483.1 DUF932 domain-containing protein -
KNN06_RS11645 (2399679) 2399679..2400152 + 474 WP_023351915.1 antirestriction protein -
KNN06_RS11650 (2400168) 2400168..2400644 + 477 WP_001186761.1 RadC family protein -
KNN06_RS11655 (2400707) 2400707..2400928 + 222 WP_000692315.1 DUF987 domain-containing protein -
KNN06_RS11660 (2400947) 2400947..2401591 + 645 WP_000086757.1 hypothetical protein -
KNN06_RS11665 (2401641) 2401641..2402021 + 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KNN06_RS11670 (2402098) 2402098..2402475 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
KNN06_RS11675 (2402472) 2402472..2402960 + 489 WP_000761698.1 DUF5983 family protein -
KNN06_RS11680 (2402977) 2402977..2403174 + 198 WP_000839250.1 DUF957 domain-containing protein -
KNN06_RS11685 (2403259) 2403259..2404104 + 846 WP_001446750.1 DUF4942 domain-containing protein -
KNN06_RS11690 (2404173) 2404173..2404568 + 396 WP_000208382.1 DUF6088 family protein -
KNN06_RS11695 (2404561) 2404561..2405494 + 934 Protein_2313 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
KNN06_RS11700 (2405911) 2405911..2406081 + 171 Protein_2314 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2405926..2406081 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T205423 WP_000854689.1 NZ_CP076301:2402098-2402475 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T205423 NZ_CP101647:3975389-3975646 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT205423 WP_001285599.1 NZ_CP076301:2401641-2402021 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT205423 NZ_CP101647:c3975564-3975232 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References