20542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2350338..2351033 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag BQ2027_RS10825 Protein ID WP_003410811.1
Coordinates 2350338..2350772 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag BQ2027_RS10830 Protein ID WP_003410814.1
Coordinates 2350779..2351033 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS10815 (BQ2027_MB2127) 2346492..2349533 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
BQ2027_RS10820 (BQ2027_MB2128) 2349526..2350359 + 834 WP_003899172.1 SWIM zinc finger family protein -
BQ2027_RS10825 (BQ2027_MB2129C) 2350338..2350772 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ2027_RS10830 (BQ2027_MB2130C) 2350779..2351033 - 255 WP_003410814.1 antitoxin Antitoxin
BQ2027_RS10835 2351049..2351306 - 258 WP_003410816.1 hypothetical protein -
BQ2027_RS10840 (BQ2027_MB2131) 2352253..2352549 + 297 WP_003410820.1 PE family protein -
BQ2027_RS10845 (BQ2027_MB2132) 2352605..2353336 + 732 WP_003900467.1 PPE family protein -
BQ2027_RS10850 (BQ2027_MB2133C) 2353876..2354622 - 747 WP_003901330.1 proteasome subunit alpha -
BQ2027_RS10855 (BQ2027_MB2134C) 2354619..2355494 - 876 WP_003411023.1 proteasome subunit beta -
BQ2027_RS10860 (BQ2027_MB2135C) 2355491..2355685 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T20542 WP_003410811.1 NC_002945:c2350772-2350338 [Mycobacterium tuberculosis variant bovis AF2122/97]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T20542 NC_002945:c2350772-2350338 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT20542 WP_003410814.1 NC_002945:c2351033-2350779 [Mycobacterium tuberculosis variant bovis AF2122/97]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT20542 NC_002945:c2351033-2350779 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References