Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 2358013..2359769 | Replicon | chromosome |
| Accession | NZ_CP076298 | ||
| Organism | Burkholderia pseudomallei strain VBP21822 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | KM155_RS27750 | Protein ID | WP_207864883.1 |
| Coordinates | 2358864..2359769 (-) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q63LW2 |
| Locus tag | KM155_RS27745 | Protein ID | WP_004195450.1 |
| Coordinates | 2358013..2358867 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KM155_RS27725 (KM155_27725) | 2353229..2354719 | - | 1491 | WP_004524006.1 | aldehyde dehydrogenase | - |
| KM155_RS27730 (KM155_27730) | 2354745..2355560 | - | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
| KM155_RS27735 (KM155_27735) | 2355553..2357226 | - | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
| KM155_RS27740 (KM155_27740) | 2357219..2358016 | - | 798 | WP_004524003.1 | SDR family oxidoreductase | - |
| KM155_RS27745 (KM155_27745) | 2358013..2358867 | - | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
| KM155_RS27750 (KM155_27750) | 2358864..2359769 | - | 906 | WP_207864883.1 | alpha/beta fold hydrolase | Toxin |
| KM155_RS27755 (KM155_27755) | 2359786..2360313 | - | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| KM155_RS27760 (KM155_27760) | 2360352..2361122 | - | 771 | WP_004524000.1 | SDR family oxidoreductase | - |
| KM155_RS27765 (KM155_27765) | 2361119..2362186 | - | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| KM155_RS27770 (KM155_27770) | 2362221..2362532 | - | 312 | WP_004184841.1 | hypothetical protein | - |
| KM155_RS27775 (KM155_27775) | 2362534..2362851 | - | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| KM155_RS27780 (KM155_27780) | 2363286..2364374 | + | 1089 | WP_004184835.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30528.63 Da Isoelectric Point: 8.4944
>T205405 WP_207864883.1 NZ_CP076298:c2359769-2358864 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVALLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVALLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T205405 NZ_CP101618:27606-27911 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT205405 WP_004195450.1 NZ_CP076298:c2358867-2358013 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT205405 NZ_CP101618:27386-27604 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|