Detailed information of TA system TA205403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1339154..1340907
• Replicon: chromosome
• Accession: NZ_CP076298
• Organism: Burkholderia pseudomallei strain VBP21822

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q63JY0
• Locus tag: KM155_RS23610
• Protein ID: WP_004188815.1
• Coordinates: 1339154..1340506 (-)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KM155_RS23615
• Protein ID: WP_004188446.1
• Coordinates: 1340503..1340907 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM155_RS23590 (KM155_23590)	1336083..1337036	-	954	WP_004187785.1	agmatinase	-
KM155_RS23595 (KM155_23595)	1337203..1338117	+	915	WP_004545706.1	LysR family transcriptional regulator	-
KM155_RS23600 (KM155_23600)	1338287..1338433	+	147	WP_004199790.1	hypothetical protein	-
KM155_RS23605 (KM155_23605)	1338534..1338986	+	453	WP_004198842.1	hypothetical protein	-
KM155_RS23610 (KM155_23610)	1339154..1340506	-	1353	WP_004188815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KM155_RS23615 (KM155_23615)	1340503..1340907	-	405	WP_004188446.1	helix-turn-helix transcriptional regulator	Antitoxin
KM155_RS23620 (KM155_23620)	1341245..1341508	-	264	WP_004199789.1	hypothetical protein	-
KM155_RS23625 (KM155_23625)	1341973..1344369	+	2397	WP_080364570.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1333270..1341956	8686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-71)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 49848.83 Da
• Isoelectric Point: 9.6807

>T205403 WP_004188815.1 NZ_CP076298:c1340506-1339154 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Nucleotide

• Length: 1353 bp

>T205403 NZ_CP101618:c8567-8187 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14392.75 Da
• Isoelectric Point: 11.7233

>AT205403 WP_004188446.1 NZ_CP076298:c1340907-1340503 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTVANARAGARRAVPPASAPAPSAAGRPPRPARKRAAPKKREDW

Nucleotide

• Length: 405 bp

>AT205403 NZ_CP101618:c8788-8567 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A3N4FSX2