Detailed information of TA system TA205402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1398321..1398877
• Replicon: chromosome
• Accession: NZ_CP076297
• Organism: Burkholderia pseudomallei strain VBP21822

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KM155_RS06610
• Protein ID: WP_229655145.1
• Coordinates: 1398626..1398877 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KM155_RS06605
• Protein ID: WP_038780841.1
• Coordinates: 1398321..1398599 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM155_RS06580 (KM155_06580)	1393427..1394547	+	1121	WP_207864366.1	IS3 family transposase	-
KM155_RS06585 (KM155_06585)	1394592..1395110	-	519	WP_207418111.1	hypothetical protein	-
KM155_RS06590 (KM155_06590)	1395191..1395448	-	258	WP_076927500.1	hypothetical protein	-
KM155_RS06595 (KM155_06595)	1395937..1396206	+	270	WP_183159590.1	plasmid mobilization protein MobA	-
KM155_RS06600 (KM155_06600)	1396209..1398218	+	2010	WP_223872105.1	relaxase/mobilization nuclease domain-containing protein	-
KM155_RS06605 (KM155_06605)	1398321..1398599	+	279	WP_038780841.1	CopG family ribbon-helix-helix protein	Antitoxin
KM155_RS06610 (KM155_06610)	1398626..1398877	+	252	WP_229655145.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KM155_RS06615 (KM155_06615)	1398880..1399182	+	303	WP_038780836.1	hypothetical protein	-
KM155_RS32725	1399175..1399303	+	129	WP_256704163.1	hypothetical protein	-
KM155_RS06620 (KM155_06620)	1399383..1399634	+	252	WP_198046342.1	hypothetical protein	-
KM155_RS06625 (KM155_06625)	1399776..1403057	+	3282	WP_198046341.1	VPA1262 family protein	-
KM155_RS06630 (KM155_06630)	1403091..1403612	-	522	WP_038780832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1384790..1405183	20393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9556.78 Da
• Isoelectric Point: 9.5559

>T205402 WP_229655145.1 NZ_CP076297:1398626-1398877 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T205402 NZ_CP101616:c24227-23847 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10853.13 Da
• Isoelectric Point: 4.8052

>AT205402 WP_038780841.1 NZ_CP076297:1398321-1398599 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK

Nucleotide

• Length: 279 bp

>AT205402 NZ_CP101616:c24448-24227 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA