Detailed information of TA system TA205377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1583088..1584676
• Replicon: chromosome
• Accession: NZ_CP076285
• Organism: Escherichia coli strain 41

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: A7A12_RS07610
• Protein ID: WP_001125463.1
• Coordinates: 1583088..1584410 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: A7A12_RS07615
• Protein ID: WP_001296726.1
• Coordinates: 1584410..1584676 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A12_RS07595 (1580501)	1580501..1581211	-	711	WP_001195172.1	fimbria/pilus periplasmic chaperone	-
A7A12_RS07600 (1581572)	1581572..1582135	-	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
A7A12_RS07605 (1582568)	1582568..1582776	-	209	Protein_1485	AraC family transcriptional regulator	-
A7A12_RS07610 (1583088)	1583088..1584410	-	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
A7A12_RS07615 (1584410)	1584410..1584676	-	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T205377 WP_001125463.1 NZ_CP076285:c1584410-1583088 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T205377 NZ_CP101597:c23300-22929 [Cronobacter dublinensis]
TTGGCGTGGGAAATTGAAACACGGATTCTTTTCGATACCTGGTTTGAAGAGCAGGAAGAAGATGTACAGGAAGAGATCTT
AGCTTACTTCGAAATTCTTGAAGGGGAAGGCCCGAACTTAGGTCGACCGCATGTAGATTCGGTTAACGGTTCGGACTATA
CGAATATGAAGGAGCTAAGAGTACAGGTCGGGGGACACCCTTACCGCCTGTTCTTTGCGTTTGACCCGGCGCGTAAAGCG
ATAGTCTTATGCGGCGGTAACAAAAAAGGCTTGGTCGAAAAAGACTTCTACAAAAAGATGATCAAAATAGCAGATGCGGA
ATATGCTTCGCATCTGAAATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT205377 WP_001296726.1 NZ_CP076285:c1584676-1584410 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT205377 NZ_CP101597:c22942-22643 [Cronobacter dublinensis]
ATGGCGACGCTTAAAGAAATGATGGCGAAACGTTCACCGGAAAGCCGCGCACGTATCGCAGCGCGTACCGCTGAAATCCG
CCAGGAAATCACCCTTGCAAAACTGCGCGATGAACTGAACGTATCGCAGACGCAGTTAGCCGCCGTGCTGGGTGTTAGTC
AGCCTTCTATTGTGAAGTTGGAGAAAGTCGAAAACGACCCGAAACTGTCAACGCTGAAACGCTATGTTACCGCCCTGGGT
GGCGAACTGGCGCTAGATGTAACCCTGCCCGATGGTAAGCGTATCGCGCTCACCCTGTAA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0