Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4677152..4677747 Replicon chromosome
Accession NZ_CP076282
Organism Escherichia coli strain 442/2

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag A7A15_RS22810 Protein ID WP_000239576.1
Coordinates 4677397..4677747 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag A7A15_RS22805 Protein ID WP_001223208.1
Coordinates 4677152..4677403 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A15_RS22795 (4672817) 4672817..4676596 + 3780 WP_096843851.1 autotransporter assembly complex protein TamB -
A7A15_RS22800 (4676599) 4676599..4676940 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
A7A15_RS22805 (4677152) 4677152..4677403 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
A7A15_RS22810 (4677397) 4677397..4677747 + 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
A7A15_RS22815 (4677827) 4677827..4678357 - 531 WP_000055075.1 inorganic diphosphatase -
A7A15_RS22820 (4678667) 4678667..4679623 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
A7A15_RS22825 (4679763) 4679763..4681265 + 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
A7A15_RS22830 (4681279) 4681279..4682301 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T205359 WP_000239576.1 NZ_CP076282:4677397-4677747 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T205359 NZ_CP101591:c2605987-2605884 [Cronobacter dublinensis]
GGCAAGGCGACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT205359 WP_001223208.1 NZ_CP076282:4677152-4677403 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT205359 NZ_CP101591:2605881-2606022 [Cronobacter dublinensis]
GATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAGTCGCCTTGCCATTTAAGAATAGATGACGACAGCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References