Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
| Location | 4677152..4677747 | Replicon | chromosome |
| Accession | NZ_CP076282 | ||
| Organism | Escherichia coli strain 442/2 | ||
Toxin (Protein)
| Gene name | chpB | Uniprot ID | A0A3L3YDL1 |
| Locus tag | A7A15_RS22810 | Protein ID | WP_000239576.1 |
| Coordinates | 4677397..4677747 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | chpS | Uniprot ID | U9Y2K1 |
| Locus tag | A7A15_RS22805 | Protein ID | WP_001223208.1 |
| Coordinates | 4677152..4677403 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A15_RS22795 (4672817) | 4672817..4676596 | + | 3780 | WP_096843851.1 | autotransporter assembly complex protein TamB | - |
| A7A15_RS22800 (4676599) | 4676599..4676940 | + | 342 | WP_001219160.1 | gamma-glutamylcyclotransferase | - |
| A7A15_RS22805 (4677152) | 4677152..4677403 | + | 252 | WP_001223208.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
| A7A15_RS22810 (4677397) | 4677397..4677747 | + | 351 | WP_000239576.1 | endoribonuclease toxin ChpB | Toxin |
| A7A15_RS22815 (4677827) | 4677827..4678357 | - | 531 | WP_000055075.1 | inorganic diphosphatase | - |
| A7A15_RS22820 (4678667) | 4678667..4679623 | + | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
| A7A15_RS22825 (4679763) | 4679763..4681265 | + | 1503 | WP_000205795.1 | sugar ABC transporter ATP-binding protein | - |
| A7A15_RS22830 (4681279) | 4681279..4682301 | + | 1023 | WP_001296689.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12566.53 Da Isoelectric Point: 6.2232
>T205359 WP_000239576.1 NZ_CP076282:4677397-4677747 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
>T205359 NZ_CP101591:c2605987-2605884 [Cronobacter dublinensis]
GGCAAGGCGACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT
GGCAAGGCGACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT
Antitoxin
Download Length: 84 a.a. Molecular weight: 9271.58 Da Isoelectric Point: 4.4201
>AT205359 WP_001223208.1 NZ_CP076282:4677152-4677403 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT205359 NZ_CP101591:2605881-2606022 [Cronobacter dublinensis]
GATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAGTCGCCTTGCCATTTAAGAATAGATGACGACAGCAGCTTTTCCAGT
GATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAGTCGCCTTGCCATTTAAGAATAGATGACGACAGCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3YDL1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LQ26 |