Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 3784098..3784729 | Replicon | chromosome |
Accession | NZ_CP076282 | ||
Organism | Escherichia coli strain 442/2 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | F4NNK6 |
Locus tag | A7A15_RS18585 | Protein ID | WP_001259388.1 |
Coordinates | 3784454..3784729 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | A7A15_RS18580 | Protein ID | WP_000593555.1 |
Coordinates | 3784098..3784457 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7A15_RS18550 (3779210) | 3779210..3779683 | + | 474 | WP_001161553.1 | PTS sugar transporter subunit IIA | - |
A7A15_RS18555 (3779680) | 3779680..3779961 | + | 282 | WP_000084022.1 | PTS sugar transporter subunit IIB | - |
A7A15_RS18560 (3780038) | 3780038..3781396 | + | 1359 | WP_001298729.1 | PTS galactitol transporter subunit IIC | - |
A7A15_RS18565 (3781389) | 3781389..3782897 | + | 1509 | WP_001298718.1 | FGGY-family carbohydrate kinase | - |
A7A15_RS18570 (3782887) | 3782887..3783156 | + | 270 | WP_000933060.1 | HPr family phosphocarrier protein | - |
A7A15_RS18575 (3783188) | 3783188..3784048 | + | 861 | WP_001131783.1 | class II aldolase | - |
A7A15_RS18580 (3784098) | 3784098..3784457 | - | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
A7A15_RS18585 (3784454) | 3784454..3784729 | - | 276 | WP_001259388.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
A7A15_RS18590 (3784802) | 3784802..3785926 | - | 1125 | WP_001216257.1 | ABC transporter permease | - |
A7A15_RS18595 (3785926) | 3785926..3788661 | - | 2736 | WP_000149124.1 | ribosome-associated ATPase/putative transporter RbbA | - |
A7A15_RS18600 (3788658) | 3788658..3789725 | - | 1068 | WP_000361467.1 | HlyD family secretion protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10151.89 Da Isoelectric Point: 10.7076
>T205356 WP_001259388.1 NZ_CP076282:c3784729-3784454 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T205356 NZ_CP101571:1604-1870 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT205356 WP_000593555.1 NZ_CP076282:c3784457-3784098 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT205356 NZ_CP101571:1396-1620 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A0FFA2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |