Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2199725..2200269 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | BQ2027_RS10135 | Protein ID | WP_003409896.1 |
| Coordinates | 2199725..2200021 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | BQ2027_RS10140 | Protein ID | WP_003409899.1 |
| Coordinates | 2200018..2200269 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS10080 (BQ2027_MB1983C) | 2194758..2195108 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| BQ2027_RS10085 (BQ2027_MB1984C) | 2195119..2196021 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| BQ2027_RS10090 (BQ2027_MB1985C) | 2196042..2196233 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| BQ2027_RS10095 (BQ2027_MB1986C) | 2196234..2196530 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| BQ2027_RS10100 (BQ2027_MB1987) | 2196770..2196985 | + | 216 | WP_003409878.1 | antitoxin | - |
| BQ2027_RS10105 (BQ2027_MB1988) | 2196982..2197293 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| BQ2027_RS10110 (BQ2027_MB1989C) | 2197267..2197788 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| BQ2027_RS10115 (BQ2027_MB1990) | 2197763..2198140 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| BQ2027_RS10120 (BQ2027_MB1991) | 2198182..2198631 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| BQ2027_RS10125 (BQ2027_MB1992) | 2198628..2199173 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| BQ2027_RS10130 (BQ2027_MB1993C) | 2199062..2199676 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| BQ2027_RS10135 (BQ2027_MB1994C) | 2199725..2200021 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BQ2027_RS10140 (BQ2027_MB1995C) | 2200018..2200269 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| BQ2027_RS10145 (BQ2027_MB1996) | 2200256..2200750 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| BQ2027_RS10150 (BQ2027_MB1997C) | 2200910..2201317 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| BQ2027_RS10155 (BQ2027_MB1997A) | 2201321..2201593 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| BQ2027_RS10160 (BQ2027_MB1998C) | 2201626..2202846 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| BQ2027_RS10165 (BQ2027_MB1999) | 2203745..2204050 | + | 306 | Protein_2034 | ABC transporter permease | - |
| BQ2027_RS20405 | 2204046..2204126 | + | 81 | Protein_2035 | hypothetical protein | - |
| BQ2027_RS10170 (BQ2027_MB2000) | 2204234..2205082 | + | 849 | WP_010950638.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T20535 WP_003409896.1 NC_002945:c2200021-2199725 [Mycobacterium tuberculosis variant bovis AF2122/97]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T20535 NC_002945:c2200021-2199725 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT20535 WP_003409899.1 NC_002945:c2200269-2200018 [Mycobacterium tuberculosis variant bovis AF2122/97]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT20535 NC_002945:c2200269-2200018 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |