Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4189774..4190609 Replicon chromosome
Accession NZ_CP076279
Organism Escherichia coli strain SA53-3

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag A7A19_RS20755 Protein ID WP_097332731.1
Coordinates 4190232..4190609 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A7A19_RS20750 Protein ID WP_097332732.1
Coordinates 4189774..4190142 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A19_RS20715 (4186396) 4186396..4186851 + 456 WP_000581502.1 IrmA family protein -
A7A19_RS20720 (4186869) 4186869..4187240 + 372 WP_252505442.1 DUF905 family protein -
A7A19_RS20725 (4187261) 4187261..4188082 + 822 WP_257122657.1 DUF932 domain-containing protein -
A7A19_RS20730 (4188082) 4188082..4188327 + 246 WP_000680586.1 hypothetical protein -
A7A19_RS20735 (4188421) 4188421..4188894 + 474 WP_032330754.1 antirestriction protein -
A7A19_RS20740 (4188910) 4188910..4189386 + 477 WP_001186771.1 RadC family protein -
A7A19_RS20745 (4189473) 4189473..4189694 + 222 WP_000692350.1 DUF987 domain-containing protein -
A7A19_RS20750 (4189774) 4189774..4190142 + 369 WP_097332732.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A7A19_RS20755 (4190232) 4190232..4190609 + 378 WP_097332731.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
A7A19_RS20760 (4190606) 4190606..4191094 + 489 WP_000779174.1 DUF5983 family protein -
A7A19_RS20765 (4191106) 4191106..4191303 + 198 WP_021531598.1 DUF957 domain-containing protein -
A7A19_RS20770 (4191388) 4191388..4192233 + 846 WP_001280530.1 DUF4942 domain-containing protein -
A7A19_RS20775 (4192468) 4192468..4192629 + 162 Protein_4066 virulence RhuM family protein -
A7A19_RS20780 (4193026) 4193026..4194210 + 1185 WP_001172876.1 sugar efflux transporter -
A7A19_RS20785 (4194321) 4194321..4195244 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14088.07 Da        Isoelectric Point: 7.2436

>T205322 WP_097332731.1 NZ_CP076279:4190232-4190609 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T205322 NZ_CP101555:146875-147357 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13506.21 Da        Isoelectric Point: 5.5275

>AT205322 WP_097332732.1 NZ_CP076279:4189774-4190142 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPSHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT205322 NZ_CP101555:146621-146887 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References