20532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957511..1957971 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag BQ2027_RS09025 Protein ID WP_003408531.1
Coordinates 1957723..1957971 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag BQ2027_RS09020 Protein ID WP_003408528.1
Coordinates 1957511..1957723 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS09005 (BQ2027_MB1766C) 1953989..1955176 - 1188 WP_003898992.1 nitrate transporter NarK -
BQ2027_RS09010 (BQ2027_MB1767) 1955463..1955747 + 285 WP_003408522.1 DUF1876 domain-containing protein -
BQ2027_RS09015 (BQ2027_MB1768C) 1955761..1957443 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
BQ2027_RS09020 (BQ2027_MB1769) 1957511..1957723 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BQ2027_RS09025 (BQ2027_MB1770) 1957723..1957971 + 249 WP_003408531.1 hypothetical protein Toxin
BQ2027_RS09030 (BQ2027_MB1771) 1957979..1958717 + 739 Protein_1810 hypothetical protein -
BQ2027_RS09035 (BQ2027_MB1772) 1958811..1960511 + 1701 WP_010950585.1 serine/threonine protein kinase PknE -
BQ2027_RS09040 (BQ2027_MB1773C) 1960796..1961197 - 402 WP_010950586.1 hypothetical protein -
BQ2027_RS09045 (BQ2027_MB1774C) 1961187..1961798 - 612 Protein_1813 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T20532 WP_003408531.1 NC_002945:1957723-1957971 [Mycobacterium tuberculosis variant bovis AF2122/97]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T20532 NC_002945:1957723-1957971 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT20532 WP_003408528.1 NC_002945:1957511-1957723 [Mycobacterium tuberculosis variant bovis AF2122/97]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT20532 NC_002945:1957511-1957723 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References