Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 3241015..3241700 Replicon chromosome
Accession NZ_CP076279
Organism Escherichia coli strain SA53-3

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag A7A19_RS16160 Protein ID WP_257122604.1
Coordinates 3241015..3241323 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A7A19_RS16165 Protein ID WP_097446463.1
Coordinates 3241344..3241700 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A19_RS16130 (3236176) 3236176..3236943 - 768 WP_000503284.1 type III secretion system export apparatus subunit SctT -
A7A19_RS16135 (3236945) 3236945..3237205 - 261 WP_000341004.1 EscS/YscS/HrcS family type III secretion system export apparatus protein -
A7A19_RS16140 (3237215) 3237215..3237880 - 666 WP_000071535.1 EscR/YscR/HrcR family type III secretion system export apparatus protein -
A7A19_RS16145 (3237870) 3237870..3238857 - 988 Protein_3157 YscQ/HrcQ family type III secretion apparatus protein -
A7A19_RS16150 (3238817) 3238817..3238936 - 120 Protein_3158 type III secretion protein -
A7A19_RS16155 (3238949) 3238949..3240559 - 1611 WP_000676929.1 glycoside hydrolase family 15 protein -
A7A19_RS16160 (3241015) 3241015..3241323 - 309 WP_257122604.1 toxin Toxin
A7A19_RS16165 (3241344) 3241344..3241700 - 357 WP_097446463.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A7A19_RS16170 (3241726) 3241726..3241947 - 222 WP_097446462.1 DUF987 family protein -
A7A19_RS16175 (3241944) 3241944..3242486 - 543 WP_257122605.1 DNA repair protein RadC -
A7A19_RS16180 (3242499) 3242499..3242942 - 444 WP_097446460.1 antirestriction protein -
A7A19_RS16185 (3242973) 3242973..3243794 - 822 WP_257122606.1 DUF932 domain-containing protein -
A7A19_RS16190 (3243893) 3243893..3244123 - 231 WP_096836431.1 DUF905 domain-containing protein -
A7A19_RS16195 (3244195) 3244195..3244644 - 450 WP_015699704.1 IrmA family protein -
A7A19_RS16200 (3244641) 3244641..3245093 - 453 WP_000737933.1 hypothetical protein -
A7A19_RS16205 (3245130) 3245130..3245699 - 570 WP_097446458.1 hypothetical protein -
A7A19_RS16210 (3245699) 3245699..3246403 - 705 WP_257122607.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-97)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11750.70 Da        Isoelectric Point: 5.6467

>T205318 WP_257122604.1 NZ_CP076279:c3241323-3241015 [Escherichia coli]
MKFLPTTNMRAARPCLSSVAVWQMLLTRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPSLTIIDIMRAVAIWV

Download         Length: 309 bp

>T205318 NZ_CP101554:c4879222-4878881 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACCTTACCTGCAACAATTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACGGTCTGGCAGATGCTGCTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTACCCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCAGGCATCACACTGGTTGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTGGGCGCAGTGGATATTTTGCGGGCGCGGCAGGCAACCGGCCTGTTACGGCAAAG
ACATCTTCCTTCGATACGCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13101.83 Da        Isoelectric Point: 5.4702

>AT205318 WP_097446463.1 NZ_CP076279:c3241700-3241344 [Escherichia coli]
MNNHSESGAIPENPACQQWGLKRAMTPCFGARLVQEGDRLHFLADRAGFNGAFCDDDALYLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT205318 NZ_CP101554:c4879572-4879246 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAATTTGGTGACGCCGAATGTCTGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References