20531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1936779..1937392 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag BQ2027_RS08915 Protein ID WP_003408465.1
Coordinates 1936779..1937168 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag BQ2027_RS08920 Protein ID WP_003408469.1
Coordinates 1937165..1937392 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS08885 1932409..1933323 + 915 Protein_1781 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein -
BQ2027_RS08890 (BQ2027_MB1744) 1933326..1934156 + 831 WP_003408448.1 cyclase family protein -
BQ2027_RS08895 (BQ2027_MB1745) 1934156..1934506 + 351 WP_003898986.1 cupin domain-containing protein -
BQ2027_RS08900 (BQ2027_MB1746) 1934559..1935376 + 818 Protein_1784 3-keto-5-aminohexanoate cleavage protein -
BQ2027_RS08905 (BQ2027_MB1748) 1935390..1936169 + 780 WP_003408460.1 IclR family transcriptional regulator -
BQ2027_RS20390 (BQ2027_IS1540'-1) 1936600..1936731 + 132 Protein_1786 IS3 family transposase -
BQ2027_RS08915 (BQ2027_MB1749C) 1936779..1937168 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ2027_RS08920 (BQ2027_MB1750C) 1937165..1937392 - 228 WP_003408469.1 antitoxin Antitoxin
BQ2027_RS08925 (BQ2027_MB1751) 1937610..1939094 + 1485 WP_010950580.1 biotin carboxylase -
BQ2027_RS08930 (BQ2027_MB1752) 1939091..1940338 + 1248 WP_003408476.1 serine hydrolase -
BQ2027_RS08935 (BQ2027_MB1753C) 1940381..1940800 - 420 WP_003408483.1 hypothetical protein -
BQ2027_RS08940 (BQ2027_MB1754C) 1940790..1941500 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T20531 WP_003408465.1 NC_002945:c1937168-1936779 [Mycobacterium tuberculosis variant bovis AF2122/97]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T20531 NC_002945:c1937168-1936779 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT20531 WP_003408469.1 NC_002945:c1937392-1937165 [Mycobacterium tuberculosis variant bovis AF2122/97]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT20531 NC_002945:c1937392-1937165 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References