205300

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 460550..461387 Replicon chromosome
Accession NZ_CP076279
Organism Escherichia coli strain SA53-3

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag A7A19_RS02090 Protein ID WP_000227784.1
Coordinates 460550..461092 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag A7A19_RS02095 Protein ID WP_001297137.1
Coordinates 461076..461387 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A19_RS02070 (456089) 456089..457000 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
A7A19_RS02075 (457168) 457168..457659 + 492 WP_001138904.1 nucleotide binding protein YajQ -
A7A19_RS02080 (457787) 457787..459151 - 1365 WP_001000974.1 MFS transporter -
A7A19_RS02085 (459559) 459559..460494 + 936 WP_001365761.1 tetratricopeptide repeat protein -
A7A19_RS02090 (460550) 460550..461092 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
A7A19_RS02095 (461076) 461076..461387 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
A7A19_RS02100 (461572) 461572..462462 - 891 WP_000971336.1 heme o synthase -
A7A19_RS02105 (462474) 462474..462803 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
A7A19_RS02110 (462803) 462803..463417 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
A7A19_RS02115 (463407) 463407..465398 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
A7A19_RS02120 (465420) 465420..466367 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T205300 WP_000227784.1 NZ_CP076279:c461092-460550 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T205300 NZ_CP101546:1966424-1966526 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT205300 WP_001297137.1 NZ_CP076279:c461387-461076 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT205300 NZ_CP101546:c1966533-1966388 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References