Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 5028201..5029536 | Replicon | chromosome |
| Accession | NZ_CP076274 | ||
| Organism | Escherichia coli strain P393-F10 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | F4VMR9 |
| Locus tag | A7A10_RS24695 | Protein ID | WP_000342497.1 |
| Coordinates | 5028589..5029536 (+) | Length | 316 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A228Z6F8 |
| Locus tag | A7A10_RS24690 | Protein ID | WP_000152739.1 |
| Coordinates | 5028201..5028596 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A10_RS24675 (5024273) | 5024273..5025439 | - | 1167 | WP_001293040.1 | restriction endonuclease subunit S | - |
| A7A10_RS24680 (5025436) | 5025436..5026992 | - | 1557 | WP_000202816.1 | type I restriction-modification system subunit M | - |
| A7A10_RS24685 (5027298) | 5027298..5028131 | + | 834 | Protein_4816 | DUF4942 domain-containing protein | - |
| A7A10_RS24690 (5028201) | 5028201..5028596 | + | 396 | WP_000152739.1 | DUF6088 family protein | Antitoxin |
| A7A10_RS24695 (5028589) | 5028589..5029536 | + | 948 | WP_000342497.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| A7A10_RS24700 (5029858) | 5029858..5030001 | - | 144 | Protein_4819 | HNH endonuclease | - |
| A7A10_RS24705 (5030138) | 5030138..5030788 | + | 651 | WP_001037963.1 | HNH endonuclease | - |
| A7A10_RS24710 (5030796) | 5030796..5031776 | - | 981 | WP_257185781.1 | sialate O-acetylesterase | - |
| A7A10_RS24715 (5031841) | 5031841..5032947 | - | 1107 | WP_001298927.1 | N-acetylneuraminate epimerase | - |
| A7A10_RS24720 (5032967) | 5032967..5033683 | - | 717 | WP_001295734.1 | N-acetylneuraminic acid outer membrane channel NanC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB / fimE / fimA / fimI / fimC | 5027826..5039209 | 11383 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 316 a.a. Molecular weight: 35588.79 Da Isoelectric Point: 4.9737
>T205249 WP_000342497.1 NZ_CP076274:5028589-5029536 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
Download Length: 948 bp
>T205249 NZ_CP101525:1980533-1980952 [Burkholderia arboris]
ATGATCCTGGTTGATACGAACGTCATGTCCGAACCGTTGCGGCGCGAGCCGAGCGCGGCGGTGATCGAGTGGCTCGATGC
TCAGAACGTCGAGACGCTGTTTCTATCCGCGATCAGTCTCGCGGAATTGCGGTTCGGCGTGGCGGGATTGCCGGAAGGGC
GCAGGCGTGACTGGCTGCATCAAGGCATCGAGCAGCGTGTCGTTCCATTGTTTCGAGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTACGCGAGCCTTTGCGCGCGGGCGCGTGCCGCAGGCACCGCGCTTGCCGTCGTCGATGGTCACAT
TGCCGCGACGGCCGAGGCAAACGGCCTGATCGTGGCGACACGCGACGTCGCGCCGTTCGAGGCGGTGGGGCTTCGGGTCA
TCGACCCGTGGGCGCGATAG
ATGATCCTGGTTGATACGAACGTCATGTCCGAACCGTTGCGGCGCGAGCCGAGCGCGGCGGTGATCGAGTGGCTCGATGC
TCAGAACGTCGAGACGCTGTTTCTATCCGCGATCAGTCTCGCGGAATTGCGGTTCGGCGTGGCGGGATTGCCGGAAGGGC
GCAGGCGTGACTGGCTGCATCAAGGCATCGAGCAGCGTGTCGTTCCATTGTTTCGAGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTACGCGAGCCTTTGCGCGCGGGCGCGTGCCGCAGGCACCGCGCTTGCCGTCGTCGATGGTCACAT
TGCCGCGACGGCCGAGGCAAACGGCCTGATCGTGGCGACACGCGACGTCGCGCCGTTCGAGGCGGTGGGGCTTCGGGTCA
TCGACCCGTGGGCGCGATAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14605.90 Da Isoelectric Point: 11.6915
>AT205249 WP_000152739.1 NZ_CP076274:5028201-5028596 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
Download Length: 396 bp
>AT205249 NZ_CP101525:1980297-1980536 [Burkholderia arboris]
ATGCCGGCGATCACCGTTCGAAATTTGCCTGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCGGCACGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATCCTCGAGCAGGCCGTCTTGCCAGGTGGGCGGCTCAAGTTGGGAACGTTGCTGGCGG
AAATCGGGCGAGCGGCCGGCGATGCCGACTTCAGCGTCCCGCGCGACAAGACGCCAACCGAGCCGATGGGCTTCGAATGA
ATGCCGGCGATCACCGTTCGAAATTTGCCTGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCGGCACGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATCCTCGAGCAGGCCGTCTTGCCAGGTGGGCGGCTCAAGTTGGGAACGTTGCTGGCGG
AAATCGGGCGAGCGGCCGGCGATGCCGACTTCAGCGTCCCGCGCGACAAGACGCCAACCGAGCCGATGGGCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1L5BAQ6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A228Z6F8 |