Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5018787..5019622 Replicon chromosome
Accession NZ_CP076274
Organism Escherichia coli strain P393-F10

Toxin (Protein)


Gene name yeeV Uniprot ID V0Z9U3
Locus tag A7A10_RS24650 Protein ID WP_000854750.1
Coordinates 5019245..5019622 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J7L0S7
Locus tag A7A10_RS24645 Protein ID WP_001278231.1
Coordinates 5018787..5019155 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A10_RS24610 (5014592) 5014592..5015272 + 681 WP_001282912.1 WYL domain-containing protein -
A7A10_RS24615 (5015423) 5015423..5016100 + 678 WP_161620543.1 hypothetical protein -
A7A10_RS24620 (5016106) 5016106..5016339 + 234 WP_001278282.1 DUF905 family protein -
A7A10_RS24625 (5016429) 5016429..5017247 + 819 WP_257185780.1 DUF932 domain-containing protein -
A7A10_RS24630 (5017339) 5017339..5017824 + 486 WP_000206658.1 antirestriction protein -
A7A10_RS24635 (5017840) 5017840..5018316 + 477 WP_001367707.1 RadC family protein -
A7A10_RS24640 (5018403) 5018403..5018624 + 222 WP_000691819.1 DUF987 domain-containing protein -
A7A10_RS24645 (5018787) 5018787..5019155 + 369 WP_001278231.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A7A10_RS24650 (5019245) 5019245..5019622 + 378 WP_000854750.1 TA system toxin CbtA family protein Toxin
A7A10_RS24655 (5019619) 5019619..5020107 + 489 WP_000761685.1 DUF5983 family protein -
A7A10_RS24660 (5020119) 5020119..5020316 + 198 WP_000839280.1 DUF957 domain-containing protein -
A7A10_RS24665 (5020401) 5020401..5020544 + 144 Protein_4812 hypothetical protein -
A7A10_RS24670 (5021035) 5021035..5024151 - 3117 WP_000149674.1 HsdR family type I site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13919.90 Da        Isoelectric Point: 8.2905

>T205248 WP_000854750.1 NZ_CP076274:5019245-5019622 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T205248 NZ_CP101525:73851-74150 [Burkholderia arboris]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGCAGACGACATGGCCGACTACTTCGACGC
GTGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGTGTGATCGCCCGCGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGGCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAGTTGCACGGCTCGAAAGCGCACGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT205248 WP_001278231.1 NZ_CP076274:5018787-5019155 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLEIMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT205248 NZ_CP101525:73509-73847 [Burkholderia arboris]
ATGGTTGACATACTGCAATCGGTGCCCTACAGTGCGCCTACGTTCAGCGTCCGGACCACCGCCGTCTTCGACGCCTGGTT
TGCCGGCCTGTCCGATCGCATCGCCAGGCGCCGCATCCAGGCGCGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCGCCCATCGTCGAAATGCGCATCGATCACGGGCCCGGCTATCGCGTCTACTACGTCCGGCGTGGA
ATGCGCTGGGTGATCCTGCTCTGCGGCGGCGATAAATCAACGCAACAGGCCGATATCCGCGCCGCACACGCGATGCTTGC
GCACCTCGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0Z9U3

Antitoxin

Source ID Structure
AlphaFold DB A0A2J7L0S7

References