Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4740396..4741228 Replicon chromosome
Accession NZ_CP076274
Organism Escherichia coli strain P393-F10

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag A7A10_RS23245 Protein ID WP_000854753.1
Coordinates 4740396..4740770 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag A7A10_RS23250 Protein ID WP_001278232.1
Coordinates 4740860..4741228 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A10_RS23225 (4736749) 4736749..4738287 - 1539 WP_001187183.1 lysine decarboxylation/transport transcriptional activator CadC -
A7A10_RS23230 (4739036) 4739036..4739605 - 570 WP_001290247.1 DUF4942 domain-containing protein -
A7A10_RS23235 (4739702) 4739702..4739899 - 198 WP_000839281.1 DUF957 domain-containing protein -
A7A10_RS23240 (4739911) 4739911..4740345 - 435 WP_001556361.1 DUF5983 family protein -
A7A10_RS23245 (4740396) 4740396..4740770 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
A7A10_RS23250 (4740860) 4740860..4741228 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
A7A10_RS23255 (4741391) 4741391..4741612 - 222 WP_000692323.1 DUF987 domain-containing protein -
A7A10_RS23260 (4741675) 4741675..4742151 - 477 WP_001186726.1 RadC family protein -
A7A10_RS23265 (4742167) 4742167..4742652 - 486 WP_000849582.1 antirestriction protein -
A7A10_RS23270 (4742707) 4742707..4743525 - 819 WP_001234620.1 DUF932 domain-containing protein -
A7A10_RS23275 (4743625) 4743625..4743858 - 234 WP_001119729.1 DUF905 family protein -
A7A10_RS23280 (4743937) 4743937..4744392 - 456 Protein_4540 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4729260..4742652 13392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T205246 WP_000854753.1 NZ_CP076274:c4740770-4740396 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T205246 NZ_CP101524:1965965-1966381 [Burkholderia arboris]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCCCCCGTGGTGCTGTCGCGGTT
GCAGTCGTGCGTGAATGCGCAGCACCGGATCGTCGTGTCGGCCATTACCTACGCCGAGATGCGGTTTGGCGCGGTTGGCA
AGAAGGCGTCGCCGAAGCACGCGGAACTCGTGACGGCGTTTGTTTCGCGGCTCGATGGCGTGCTGCCGTGGGATACGGCG
GCCGTCGATGCCACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCACGCCGATCGGCACGAACGATGCGTCGATCGC
GGGGCATGCGATTGCGGCCGGCGCGGTGCTCGTCTCCCATAATGGCCGCGCATTCGGCCGTGTCGCGGGGTTGTCGCTCG
AGGATTGGGCGGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT205246 WP_001278232.1 NZ_CP076274:c4741228-4740860 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT205246 NZ_CP101524:1965705-1965968 [Burkholderia arboris]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACCTTGCTGCTGCGGCCGGTACGGCCGACGTGGCTGTCGTTCGCGAACGAAC
TGCTGGCCGATGCCGATTTCCTTGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGCTTCGACCTGTCCGGCGACGCCGAC
GCGCCGACGGAGTCCAGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References