Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
| Location | 3938338..3939138 | Replicon | chromosome |
| Accession | NZ_CP076274 | ||
| Organism | Escherichia coli strain P393-F10 | ||
Toxin (Protein)
| Gene name | ataT | Uniprot ID | F4NNI0 |
| Locus tag | A7A10_RS19550 | Protein ID | WP_000342449.1 |
| Coordinates | 3938338..3938865 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | F4NNI1 |
| Locus tag | A7A10_RS19555 | Protein ID | WP_001277108.1 |
| Coordinates | 3938872..3939138 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A10_RS19525 (3933413) | 3933413..3934180 | - | 768 | WP_000082101.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| A7A10_RS19530 (3934177) | 3934177..3935454 | - | 1278 | WP_000803771.1 | branched chain amino acid ABC transporter permease LivM | - |
| A7A10_RS19535 (3935451) | 3935451..3936377 | - | 927 | WP_001295111.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| A7A10_RS19540 (3936425) | 3936425..3937534 | - | 1110 | WP_000827696.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
| A7A10_RS19545 (3937958) | 3937958..3938341 | + | 384 | WP_000778795.1 | aspartate 1-decarboxylase autocleavage activator PanM | - |
| A7A10_RS19550 (3938338) | 3938338..3938865 | - | 528 | WP_000342449.1 | type II toxin-antitoxin system toxin acetyltransferase AtaT | Toxin |
| A7A10_RS19555 (3938872) | 3938872..3939138 | - | 267 | WP_001277108.1 | type II toxin-antitoxin system antitoxin AtaR | Antitoxin |
| A7A10_RS19560 (3939288) | 3939288..3940391 | - | 1104 | WP_001021996.1 | branched chain amino acid ABC transporter substrate-binding protein LivJ | - |
| A7A10_RS19565 (3940662) | 3940662..3941516 | - | 855 | WP_000130217.1 | RNA polymerase sigma factor RpoH | - |
| A7A10_RS19570 (3941761) | 3941761..3942819 | - | 1059 | WP_001042003.1 | permease-like cell division protein FtsX | - |
| A7A10_RS19575 (3942812) | 3942812..3943480 | - | 669 | WP_000617723.1 | cell division ATP-binding protein FtsE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19691.70 Da Isoelectric Point: 7.7457
>T205242 WP_000342449.1 NZ_CP076274:c3938865-3938338 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD
Download Length: 528 bp
>T205242 NZ_CP101519:206104-206523 [Ensifer adhaerens]
ATGATCGTCCTGGACACGAATGTCGTCTCGGAGGCGATGAAGCCGGCCCCGGATTTGGCTGTGCGCAATTGGTTGAATGA
CCAGGTAGCCGAAACCTTGTATCTGTCCAGTGTAACGCTGGCGGAACTGCTGTTTGGCATCGCTGCGCTCCCGGAAGGCC
GGCGCAAAAAAGCGTTGGCCGACACGCTTGATGGCCTGCTCGAACTGTTCGACGATCGCGTGTTGTCATTCGACACTGCG
GCGGCTCGGCACTATGCCGACCTTGCGGCCACCGCGCGAGCAGGGGGGAAGGGATTCCCGACACCTGATGGATATATTGC
GGCTATTGCAGCCTCCAAGGGATTTACAATCGCGACACGCGATACAAGCCCCTTTGAGGCGGCAGGAGTCCCTGTCGTCA
ATCCTTGGAACCACCTATAG
ATGATCGTCCTGGACACGAATGTCGTCTCGGAGGCGATGAAGCCGGCCCCGGATTTGGCTGTGCGCAATTGGTTGAATGA
CCAGGTAGCCGAAACCTTGTATCTGTCCAGTGTAACGCTGGCGGAACTGCTGTTTGGCATCGCTGCGCTCCCGGAAGGCC
GGCGCAAAAAAGCGTTGGCCGACACGCTTGATGGCCTGCTCGAACTGTTCGACGATCGCGTGTTGTCATTCGACACTGCG
GCGGCTCGGCACTATGCCGACCTTGCGGCCACCGCGCGAGCAGGGGGGAAGGGATTCCCGACACCTGATGGATATATTGC
GGCTATTGCAGCCTCCAAGGGATTTACAATCGCGACACGCGATACAAGCCCCTTTGAGGCGGCAGGAGTCCCTGTCGTCA
ATCCTTGGAACCACCTATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9910.31 Da Isoelectric Point: 10.0863
>AT205242 WP_001277108.1 NZ_CP076274:c3939138-3938872 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM
Download Length: 267 bp
>AT205242 NZ_CP101519:205853-206107 [Ensifer adhaerens]
ATGGCTATCCTGACAGTACGAAATGTACCTGATGAAGTGCACCGCGCTTTGCGCGTCCGGGCGGCAAATCACGGCCGTAG
CACAGAGGCGGAAGTCCGCGAGATTCTGGAACGTGCGGTAAAGCCCGAACAGCGTATTCGCATCGGGGATGCCTTGGCTG
AGTTGAGCGGGCGGATTGGCTTGACCAATGATGATTTTGAAGTGTTCGACCAGATGCGAGACAAAGCGCCGGCAGAGCCA
ATGAGGTTTGAATGA
ATGGCTATCCTGACAGTACGAAATGTACCTGATGAAGTGCACCGCGCTTTGCGCGTCCGGGCGGCAAATCACGGCCGTAG
CACAGAGGCGGAAGTCCGCGAGATTCTGGAACGTGCGGTAAAGCCCGAACAGCGTATTCGCATCGGGGATGCCTTGGCTG
AGTTGAGCGGGCGGATTGGCTTGACCAATGATGATTTTGAAGTGTTCGACCAGATGCGAGACAAAGCGCCGGCAGAGCCA
ATGAGGTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLZ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6GTS | |
| PDB | 6AJN | |
| PDB | 6GTQ | |
| PDB | 6GTO | |
| PDB | 6GTR | |
| PDB | 6AJM | |
| AlphaFold DB | A0A829CN24 |