Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3437378..3438210 Replicon chromosome
Accession NZ_CP076274
Organism Escherichia coli strain P393-F10

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag A7A10_RS17045 Protein ID WP_000854753.1
Coordinates 3437836..3438210 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag A7A10_RS17040 Protein ID WP_001278232.1
Coordinates 3437378..3437746 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A10_RS17010 (3434214) 3434214..3434669 + 456 Protein_3327 IrmA family protein -
A7A10_RS17015 (3434748) 3434748..3434981 + 234 WP_001119729.1 DUF905 family protein -
A7A10_RS17020 (3435081) 3435081..3435899 + 819 WP_001234620.1 DUF932 domain-containing protein -
A7A10_RS17025 (3435954) 3435954..3436439 + 486 WP_000849582.1 antirestriction protein -
A7A10_RS17030 (3436455) 3436455..3436931 + 477 WP_001186726.1 RadC family protein -
A7A10_RS17035 (3436994) 3436994..3437215 + 222 WP_000692323.1 DUF987 domain-containing protein -
A7A10_RS17040 (3437378) 3437378..3437746 + 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
A7A10_RS17045 (3437836) 3437836..3438210 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
A7A10_RS17050 (3438261) 3438261..3438695 + 435 WP_001556361.1 DUF5983 family protein -
A7A10_RS17055 (3438707) 3438707..3438904 + 198 WP_000839281.1 DUF957 domain-containing protein -
A7A10_RS17060 (3439001) 3439001..3439570 + 570 WP_001290247.1 DUF4942 domain-containing protein -
A7A10_RS17065 (3439851) 3439851..3440387 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
A7A10_RS17070 (3440389) 3440389..3441567 - 1179 WP_257185742.1 type II secretion system protein GspL -
A7A10_RS17075 (3441564) 3441564..3442541 - 978 WP_000633238.1 type II secretion system minor pseudopilin GspK -
A7A10_RS17080 (3442544) 3442544..3443143 - 600 WP_001255040.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T205240 WP_000854753.1 NZ_CP076274:3437836-3438210 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T205240 NZ_CP101518:c1659285-1658782 [Ensifer adhaerens]
GTGGCGTTATCCACTCCCGAACCGCTTACCGCCGCGCATGATGTGTCTGAATTCTCTTGCGGCAAGCCGACGCTCGATCA
CTGGCTGAAGACGCGCGCGCTTTCCAATCAGCAGAAGGGCTTCACCGCCATTTTGGTCGTCCATGAGGCGGGGCGCGTCG
TCGGCTATTATGGTCTGGCGCCGACGGCCGTGGTGCCGTCGGTCATGCCGCGCTCGATTCGCACAGGCCAGCCGCCCAAT
CCGGTTCCGTGCCTTCTTCTTGGCCAGCTTGCCACCGATACCGGATGGGCGGGGCAGGGGATTGGGACGGGTCTCGTCAA
ACACGCGCTGCAGCGTTGCGTCCAGGCGGCCGGTCTGGTGGGCGGGCGAGCGCTGATGGTCAATGCCGTGGATGATGAAG
CTGCCGGTTTCTGGCAACGGCGTGGCTTCTTGCCGTCGAAGGACGATCCACTTGTCCTCTTCCGCTCGATTGCCGATGTC
GCGGCGTCGCTGGCCGAGGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT205240 WP_001278232.1 NZ_CP076274:3437378-3437746 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT205240 NZ_CP101518:c1659588-1659289 [Ensifer adhaerens]
ATGGCCACCACAGCGGAACGCAAGGAACACCCCATCTCGATGCGACTGCCGGAAGCGGATGTCGCGATGATCGATCGTGC
GGCGTCGCTGCGCGGCCGCTCGCGCACCGACTTCGTGCGCGATGCCGCCGTGCGCGCGGCCGAGGAGGTCGTGATGGAGC
AAAGCCTGATCCGTATGAGCCCGGAAGGCTTCGATGCGTTCATGGAGGTTCTCGCCGCCCCGGCAGCGCCTGCTCCCGAA
ATGGTCGAGTTGGCGAAACGGCCCGCACCATGGGAAGCCGGCTACGAGCCGAAGCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References