205214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 37112..37737 Replicon plasmid pE21845IncF
Accession NZ_CP076273
Organism Escherichia coli strain E21845/O/A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A7A11_RS24645 Protein ID WP_000911315.1
Coordinates 37339..37737 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag A7A11_RS24640 Protein ID WP_000450532.1
Coordinates 37112..37339 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A11_RS24640 (37112) 37112..37339 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
A7A11_RS24645 (37339) 37339..37737 + 399 WP_000911315.1 type II toxin-antitoxin system VapC family toxin Toxin
A7A11_RS24650 (37746) 37746..39935 - 2190 WP_001352848.1 type IV conjugative transfer system coupling protein TraD -
A7A11_RS24655 (40188) 40188..40898 - 711 WP_042032882.1 conjugal transfer complement resistance protein TraT -
A7A11_RS24660 (40944) 40944..41465 - 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88425 88425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14871.17 Da        Isoelectric Point: 8.5264

>T205214 WP_000911315.1 NZ_CP076273:37339-37737 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQARPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

>T205214 NZ_CP101513:198533-198640 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT205214 WP_000450532.1 NZ_CP076273:37112-37339 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT205214 NZ_CP101513:c198485-198419 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References