205212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4781481..4782076 Replicon chromosome
Accession NZ_CP076272
Organism Escherichia coli strain E21845/O/A

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag A7A11_RS23395 Protein ID WP_000239579.1
Coordinates 4781726..4782076 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag A7A11_RS23390 Protein ID WP_001223208.1
Coordinates 4781481..4781732 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A11_RS23380 (4777146) 4777146..4780925 + 3780 WP_000060927.1 autotransporter assembly complex protein TamB -
A7A11_RS23385 (4780928) 4780928..4781269 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
A7A11_RS23390 (4781481) 4781481..4781732 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
A7A11_RS23395 (4781726) 4781726..4782076 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
A7A11_RS23400 (4782156) 4782156..4782686 - 531 WP_000055072.1 inorganic diphosphatase -
A7A11_RS23405 (4782996) 4782996..4783952 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
A7A11_RS23410 (4784092) 4784092..4785594 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
A7A11_RS23415 (4785608) 4785608..4786630 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T205212 WP_000239579.1 NZ_CP076272:4781726-4782076 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T205212 NZ_CP101497:c2213152-2212742 [Microcella sp. MMS21-STM10]
GTGGCGGTGACGCCCTGGCTGATCGACAAGTCGGCCTACGTGCGGCTCGCCGACAGTCCCGACGCCGAGCTCTGGCTCAC
CCGCATCGCCCGCGGCCTCGTGCGCATCACCGGCATCACGCAGCTCGAGATCGGGTACTCGATGCGATCAGCCGAGCAGT
CCCGCCTCGAGTTCGCGTCTCCCCCGCTCTCGCTCCTGCCCGTCGAGCACCTGACACCCGGCATCGAACGCCGCGCCCTC
GAGGTGCAGCAGCTGCTCGGCGACCGTGGTCAGCATCGCGCCCCGTCGATCCCCGACCTGCTCATCGCGGCGACGGCCGA
ACTCACGGGCTGCACCGTGCTCGCCGTCGACAAAGACTTCGACCTGGTCGCCGAGGTCACCGGTCAAGCAATCGAACGCC
TCGCGCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT205212 WP_001223208.1 NZ_CP076272:4781481-4781732 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT205212 NZ_CP101497:c2213373-2213143 [Microcella sp. MMS21-STM10]
ATGACCGACATCCTCATCCGCGGCATGAGCGACGAGTCGGTCGCGCGCATCGAAGAGCAGGCGTCGAGACTCGGGCTCTC
GCGCAACGAATACCTGCGGCGGCAGCTCGATGCGCTGGCCGACGTCCAGCGCGAGGCCCCCGCCGAGATCTCCCTCGACG
ACTTGCGCCGCGCATCCCACGCCGCCCGCGACCTCGACGACCCCGACGTGATGGCCGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References