Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1668774..1669412 Replicon chromosome
Accession NZ_CP076272
Organism Escherichia coli strain E21845/O/A

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag A7A11_RS08305 Protein ID WP_000813794.1
Coordinates 1668774..1668950 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A7A11_RS08310 Protein ID WP_001270286.1
Coordinates 1668996..1669412 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A11_RS08285 (1664393) 1664393..1665607 - 1215 WP_001307190.1 BenE family transporter YdcO -
A7A11_RS08290 (1665660) 1665660..1666196 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
A7A11_RS08295 (1666269) 1666269..1668230 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
A7A11_RS08300 (1668322) 1668322..1668552 - 231 WP_000494244.1 YncJ family protein -
A7A11_RS08305 (1668774) 1668774..1668950 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
A7A11_RS08310 (1668996) 1668996..1669412 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
A7A11_RS08315 (1669491) 1669491..1670897 + 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
A7A11_RS08320 (1671142) 1671142..1672287 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
A7A11_RS08325 (1672305) 1672305..1673318 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
A7A11_RS08330 (1673319) 1673319..1674260 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T205193 WP_000813794.1 NZ_CP076272:1668774-1668950 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T205193 NZ_CP101417:c2768976-2768725 [Xanthomonas hortorum]
ATGGACACCATCACTTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCATGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTAGTCATGTTGTCGCTGGAAGACTACAAGGCCATGGAAGAGACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT205193 WP_001270286.1 NZ_CP076272:1668996-1669412 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT205193 NZ_CP101417:c2768728-2768471 [Xanthomonas hortorum]
GTGATTCTGCAGTTTGCGGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATTGTCTATAAGGCCGAGAACGGCATCCTGCTGATTGCTCAGGCG
CGCTACCACTACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References