20519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843137..843846 Replicon chromosome
Accession NC_002945
Organism Mycobacterium bovis AF2122/97

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag BQ2027_RS03945 Protein ID WP_003403837.1
Coordinates 843418..843846 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag BQ2027_RS03940 Protein ID WP_003403834.1
Coordinates 843137..843394 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ2027_RS03935 (BQ2027_MB0768) 840317..843046 + 2730 WP_010950437.1 PE family protein -
BQ2027_RS03940 (BQ2027_MB0769) 843137..843394 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
BQ2027_RS03945 (BQ2027_MB0770) 843418..843846 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ2027_RS03950 (BQ2027_MB0771C) 843927..844064 - 138 WP_003403839.1 hypothetical protein -
BQ2027_RS03955 (BQ2027_MB0772) 844223..844468 + 246 WP_003403841.1 hypothetical protein -
BQ2027_RS03960 (BQ2027_MB0773C) 844537..845421 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
BQ2027_RS03965 (BQ2027_MB0774C) 845432..846604 - 1173 WP_010950438.1 acyl-CoA dehydrogenase family protein -
BQ2027_RS03970 (BQ2027_MB0775C) 846611..848143 - 1533 WP_010950439.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T20519 WP_003403837.1 NC_002945:843418-843846 [Mycobacterium tuberculosis variant bovis AF2122/97]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T20519 NC_002945:843418-843846 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT20519 WP_003403834.1 NC_002945:843137-843394 [Mycobacterium tuberculosis variant bovis AF2122/97]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT20519 NC_002945:843137-843394 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References