Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 93767..94292 | Replicon | plasmid pCeylon31IncF |
Accession | NZ_CP076271 | ||
Organism | Escherichia coli strain Ceylon31 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | V0SSI5 |
Locus tag | A7A14_RS24245 | Protein ID | WP_001159868.1 |
Coordinates | 93767..94072 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | S1PPD8 |
Locus tag | A7A14_RS24250 | Protein ID | WP_000813634.1 |
Coordinates | 94074..94292 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A7A14_RS24230 (89729) | 89729..90895 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
A7A14_RS24235 (91483) | 91483..92238 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
A7A14_RS24240 (92960) | 92960..93766 | - | 807 | WP_000016982.1 | site-specific integrase | - |
A7A14_RS24245 (93767) | 93767..94072 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
A7A14_RS24250 (94074) | 94074..94292 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
A7A14_RS24255 (94925) | 94925..95122 | + | 198 | WP_000215657.1 | hypothetical protein | - |
A7A14_RS24260 (95119) | 95119..95403 | - | 285 | WP_000642771.1 | hypothetical protein | - |
A7A14_RS24265 (95423) | 95423..96556 | - | 1134 | WP_000545983.1 | DUF3800 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | pefD / pefC / pefA | 1..127140 | 127140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11706.51 Da Isoelectric Point: 6.4674
>T205184 WP_001159868.1 NZ_CP076271:c94072-93767 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T205184 NZ_CP101416:961168-961518 [Pseudanabaena sp. Chao 1811]
GTGACCTTTAATCAATTTGATGTGGTTATTGTTCCTTTCCCATTTACAGATACTGCTAGTACAAAACGACGACCTGCACT
TGTAATTTCTGATCATGTCACTTTCAATGCTCCTACGAACCGCAGCGTGATGGCAATGATCACAACTGCCAAGCACTCAT
CTTGGGTTCTTGATGTCAATATTCTTGACTTGCCAAGTGCTGGATTGACGTATCCTTCTATAATTAGGATGAAATTATTT
ACTCTAGATGACGTACTGGTTATCAAGCGTATTGGAGCTTTAAGTCAAGCGGATCGAACGGCAACGCAAGAAGCGATTGC
ACAGCTTTTTAGACTAAGTCTTGAAGCTTAA
GTGACCTTTAATCAATTTGATGTGGTTATTGTTCCTTTCCCATTTACAGATACTGCTAGTACAAAACGACGACCTGCACT
TGTAATTTCTGATCATGTCACTTTCAATGCTCCTACGAACCGCAGCGTGATGGCAATGATCACAACTGCCAAGCACTCAT
CTTGGGTTCTTGATGTCAATATTCTTGACTTGCCAAGTGCTGGATTGACGTATCCTTCTATAATTAGGATGAAATTATTT
ACTCTAGATGACGTACTGGTTATCAAGCGTATTGGAGCTTTAAGTCAAGCGGATCGAACGGCAACGCAAGAAGCGATTGC
ACAGCTTTTTAGACTAAGTCTTGAAGCTTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8372.34 Da Isoelectric Point: 4.7405
>AT205184 WP_000813634.1 NZ_CP076271:c94292-94074 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT205184 NZ_CP101416:960936-961178 [Pseudanabaena sp. Chao 1811]
ATGCAGACAACACAAAAAATTCTAGCCTCAAAAGTAACTTCTAAATTTCAAGCCACAATCCCTCAAAGCATTCGCAACGC
TATGGGTATATCACAAGGGGATATAGTTGTGTTTGAAATAGAGGAGGGAAGAGTCTTTATCAAGAAATTACAGCCATTAA
ATTTAGATTACCTCAACGCAGTATCAGAAACCCTGAGTGAGTGGGCATCTCCAGAGGATGAGGAAGCATATCGTGACCTT
TAA
ATGCAGACAACACAAAAAATTCTAGCCTCAAAAGTAACTTCTAAATTTCAAGCCACAATCCCTCAAAGCATTCGCAACGC
TATGGGTATATCACAAGGGGATATAGTTGTGTTTGAAATAGAGGAGGGAAGAGTCTTTATCAAGAAATTACAGCCATTAA
ATTTAGATTACCTCAACGCAGTATCAGAAACCCTGAGTGAGTGGGCATCTCCAGAGGATGAGGAAGCATATCGTGACCTT
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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