205141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2738074..2738699 Replicon chromosome
Accession NZ_CP076268
Organism Escherichia coli strain D217-5

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag A7A16_RS13355 Protein ID WP_000911329.1
Coordinates 2738074..2738472 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag A7A16_RS13360 Protein ID WP_000450524.1
Coordinates 2738472..2738699 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A16_RS13335 (2733952) 2733952..2734152 + 201 WP_000383836.1 YpfN family protein -
A7A16_RS13340 (2734262) 2734262..2734960 - 699 WP_000679823.1 esterase -
A7A16_RS13345 (2735034) 2735034..2737049 - 2016 WP_257106847.1 tRNA cytosine(34) acetyltransferase TmcA -
A7A16_RS13350 (2737064) 2737064..2737927 - 864 WP_001267498.1 neutral zinc metallopeptidase -
A7A16_RS13355 (2738074) 2738074..2738472 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
A7A16_RS13360 (2738472) 2738472..2738699 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
A7A16_RS13365 (2738854) 2738854..2739567 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
A7A16_RS13370 (2739780) 2739780..2740814 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
A7A16_RS13375 (2740831) 2740831..2741709 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
A7A16_RS13380 (2741855) 2741855..2742427 + 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
A7A16_RS13385 (2742427) 2742427..2742897 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T205141 WP_000911329.1 NZ_CP076268:c2738472-2738074 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T205141 NZ_CP101386:c4286489-4286205 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT205141 WP_000450524.1 NZ_CP076268:c2738699-2738472 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT205141 NZ_CP101386:c4286721-4286479 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References