205125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 530638..531256 Replicon chromosome
Accession NZ_CP076268
Organism Escherichia coli strain D217-5

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag A7A16_RS02520 Protein ID WP_001291435.1
Coordinates 530638..530856 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag A7A16_RS02525 Protein ID WP_000344800.1
Coordinates 530882..531256 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A16_RS02485 (525928) 525928..526500 + 573 WP_000779826.1 YbaY family lipoprotein -
A7A16_RS02490 (526531) 526531..526842 - 312 WP_000409911.1 MGMT family protein -
A7A16_RS02500 (527221) 527221..527574 + 354 WP_000878140.1 DUF1428 domain-containing protein -
A7A16_RS02505 (527616) 527616..529166 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
A7A16_RS02510 (529330) 529330..529800 - 471 WP_000136192.1 YlaC family protein -
A7A16_RS02515 (529916) 529916..530467 - 552 WP_000102564.1 maltose O-acetyltransferase -
A7A16_RS02520 (530638) 530638..530856 - 219 WP_001291435.1 HHA domain-containing protein Toxin
A7A16_RS02525 (530882) 530882..531256 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
A7A16_RS02530 (531802) 531802..534951 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
A7A16_RS02535 (534974) 534974..536167 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205125 WP_001291435.1 NZ_CP076268:c530856-530638 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T205125 NZ_CP101382:c4270968-4270684 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT205125 WP_000344800.1 NZ_CP076268:c531256-530882 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT205125 NZ_CP101382:c4271200-4270958 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References