Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 67819..68420 | Replicon | plasmid pNADC1036IncYphage |
| Accession | NZ_CP076266 | ||
| Organism | Escherichia coli strain NADC1036 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1M0S1Q8 |
| Locus tag | A7A17_RS25025 | Protein ID | WP_024236459.1 |
| Coordinates | 67819..68199 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | A7A17_RS25030 | Protein ID | WP_001190712.1 |
| Coordinates | 68199..68420 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A17_RS24995 | 62919..63038 | - | 120 | WP_071527722.1 | ash family protein | - |
| A7A17_RS25000 (A7A17_24905) | 63260..64744 | - | 1485 | WP_046788788.1 | hypothetical protein | - |
| A7A17_RS25005 (A7A17_24910) | 64744..65937 | - | 1194 | WP_257117873.1 | terminase | - |
| A7A17_RS25010 (A7A17_24915) | 66023..66475 | - | 453 | WP_257117875.1 | Late promoter-activating protein | - |
| A7A17_RS25015 (A7A17_24920) | 66564..67607 | - | 1044 | WP_097337022.1 | DUF968 domain-containing protein | - |
| A7A17_RS25020 (A7A17_24925) | 67635..67814 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| A7A17_RS25025 (A7A17_24930) | 67819..68199 | - | 381 | WP_024236459.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| A7A17_RS25030 (A7A17_24935) | 68199..68420 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| A7A17_RS25035 (A7A17_24940) | 68493..68882 | - | 390 | WP_000506727.1 | S24 family peptidase | - |
| A7A17_RS25040 (A7A17_24945) | 69057..69638 | + | 582 | WP_089648953.1 | DNA-binding protein | - |
| A7A17_RS25045 (A7A17_24950) | 69699..70223 | - | 525 | WP_000159954.1 | toprim domain-containing protein | - |
| A7A17_RS25050 (A7A17_24955) | 70220..70525 | - | 306 | WP_000988220.1 | hypothetical protein | - |
| A7A17_RS25055 (A7A17_24960) | 70525..70809 | - | 285 | WP_001142389.1 | hypothetical protein | - |
| A7A17_RS25060 (A7A17_24965) | 70793..71473 | - | 681 | WP_257117882.1 | hypothetical protein | - |
| A7A17_RS25065 (A7A17_24970) | 71455..71829 | - | 375 | WP_000988652.1 | hypothetical protein | - |
| A7A17_RS25070 (A7A17_24975) | 71836..72129 | - | 294 | WP_097337021.1 | hypothetical protein | - |
| A7A17_RS25075 (A7A17_24980) | 72153..72434 | - | 282 | WP_096949320.1 | ASCH domain-containing protein | - |
| A7A17_RS25080 (A7A17_24985) | 72434..72691 | - | 258 | WP_097296167.1 | eaa protein | - |
| A7A17_RS25085 | 72691..72909 | - | 219 | Protein_80 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..100556 | 100556 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13643.37 Da Isoelectric Point: 5.1514
>T205122 WP_024236459.1 NZ_CP076266:c68199-67819 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T205122 NZ_CP101382:3557908-3558126 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT205122 WP_001190712.1 NZ_CP076266:c68420-68199 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT205122 NZ_CP101382:3557506-3557880 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0S1Q8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |