Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 704489..705132 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P67239 |
| Locus tag | BQ2027_RS03180 | Protein ID | WP_003403187.1 |
| Coordinates | 704731..705132 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ91 |
| Locus tag | BQ2027_RS03175 | Protein ID | WP_003403184.1 |
| Coordinates | 704489..704734 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS03140 (BQ2027_MB0617C) | 699769..700299 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
| BQ2027_RS03145 (BQ2027_MB0618C) | 700283..700978 | - | 696 | WP_197044064.1 | two-component system response regulator TcrA | - |
| BQ2027_RS03150 (BQ2027_MB0619) | 701101..701412 | + | 312 | WP_010950421.1 | hypothetical protein | - |
| BQ2027_RS03155 (BQ2027_MB0620) | 701484..702434 | + | 951 | WP_003907436.1 | DUF1259 domain-containing protein | - |
| BQ2027_RS03160 (BQ2027_MB0621) | 702675..703259 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
| BQ2027_RS03165 (BQ2027_MB0622) | 703261..703971 | + | 711 | Protein_634 | IS607 family element RNA-guided endonuclease TnpB | - |
| BQ2027_RS03170 (BQ2027_MB0623) | 703974..704444 | + | 471 | WP_003898523.1 | hypothetical protein | - |
| BQ2027_RS03175 (BQ2027_MB0624) | 704489..704734 | + | 246 | WP_003403184.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| BQ2027_RS03180 (BQ2027_MB0625) | 704731..705132 | + | 402 | WP_003403187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| BQ2027_RS20230 (BQ2027_MB0626) | 705123..705302 | + | 180 | Protein_638 | hypothetical protein | - |
| BQ2027_RS03190 (BQ2027_MB0626CA) | 705720..705917 | - | 198 | WP_003403191.1 | hypothetical protein | - |
| BQ2027_RS03195 (BQ2027_MB0627C) | 705997..707154 | - | 1158 | WP_003403193.1 | hypothetical protein | - |
| BQ2027_RS03200 | 707206..707427 | - | 222 | WP_003898525.1 | DUF4926 domain-containing protein | - |
| BQ2027_RS03205 (BQ2027_MB0629) | 707569..708174 | + | 606 | WP_003898526.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14501.21 Da Isoelectric Point: 4.4463
>T20511 WP_003403187.1 NC_002945:704731-705132 [Mycobacterium tuberculosis variant bovis AF2122/97]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
Download Length: 402 bp
>T20511 NC_002945:704731-705132 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8813.12 Da Isoelectric Point: 10.3486
>AT20511 WP_003403184.1 NC_002945:704489-704734 [Mycobacterium tuberculosis variant bovis AF2122/97]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
Download Length: 246 bp
>AT20511 NC_002945:704489-704734 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ91 |